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New treatment option for Nicotine Dependence
Official title E-cigarette Cessation in Adults Who Co-use Cannabis
ClinicalTrials.gov ID: NCT06688539
What this study is testing
What is Varenicline Pill?
Varenicline Pill is an investigational medicine, given as an injection under the skin, being studied as a potential treatment for nicotine dependence.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to better understand tobacco outcomes using a commonly prescribed stop smoking medication (varenicline) and financial incentives for adults who also use cannabis. Varenicline is not FDA approved for e-cigarette cessation, but is FDA approved for cigarette cessation.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 40. Healthy volunteers may be eligible.
You may be able to join if
- Between the ages of 18 and 40 years old
- Use e-cigarettes daily or near daily in the past month
- Must submit a positive instant-read urine cotinine test at screening (≥ 200 ng/ml)
- Be interested in quitting use of e-cigarettes
- Must be willing to take varenicline for the standard 12-week course of treatment
You likely can't join if
- Any serious or unstable medical/psychiatric disorder (including severe substance use disorders, other than cannabis or tobacco use disorders) in the...
- Use of cigarettes on 10+ days in the past 30
- Currently pregnant or breastfeeding
- Current use of medications with smoking cessation how well it works
- Use of any medications that would interfere with varenicline
See the full eligibility criteria
- Between the ages of 18 and 40 years old
- Use e-cigarettes daily or near daily in the past month
- Must submit a positive instant-read urine cotinine test at screening (≥ 200 ng/ml)
- Be interested in quitting use of e-cigarettes
- Must be willing to take varenicline for the standard 12-week course of treatment
- Self-reported use of cannabis on at least 10 out of the past 30 days or must submit a positive qualitative urinary cannabinoid test at screening (\> 50 ng/ml)
- Any serious or unstable medical/psychiatric disorder (including severe substance use disorders, other than cannabis or tobacco use disorders) in the past three months that may interfere with study performance
- Use of cigarettes on 10+ days in the past 30
- Currently pregnant or breastfeeding
- Current use of medications with smoking cessation how well it works
- Use of any medications that would interfere with varenicline
The study team makes the final eligibility decision.
Where it's taking place
- Charleston, South Carolina, United States
- Lancaster, South Carolina, United States
- Pickens, South Carolina, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 40 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Charleston, South Carolina, United States; Lancaster, South Carolina, United States; Pickens, South Carolina, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.