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Compares treatment options for Multiple Myeloma
Official title A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)
ClinicalTrials.gov ID: NCT06679101
What this study is testing
What is Belantamab mafodotin?
Belantamab mafodotin is an investigational medicine, being studied as a potential treatment for multiple myeloma.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this Phase 3 study is to evaluate if BRd prolongs progression free survival (PFS) and/or improves minimal residual disease (MRD) negative status compared with DRd in participants with TI-NDMM.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Is at least 18 or the legal age of consent in the jurisdiction in which the study is taking place, at the time of signing the informed consent.
- Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form and...
- NDMM with a requirement for treatment as documented per IMWG criteria.
- Must have at least 1 aspect of measurable disease, as assessed by the central laboratory, defined as 1 of the following:
- Urine M-protein excretion ≥200 mg/24 hours (≥0.2 g/24 hours) And/or
You likely can't join if
- Diagnosis of systemic amyloid light chain amyloidosis, Waldenstrom's disease, POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma...
- Prior systemic therapy for multiple myeloma, or smoldering multiple myeloma.
- Signs of meningeal or central nervous system involvement with multiple myeloma.
- Major surgery within 2 weeks prior to the first dose of study drugs or has not recovered fully from surgery. Kyphoplasty is not considered major...
- Any serious and/or unstable pre-existing medical, psychiatric disorder or other conditions (including lab abnormalities) that could interfere with...
- Current active liver or biliary disease (except for Gilbert's syndrome or asymptomatic gallstones, or otherwise stable chronic liver disease as per...
See the full eligibility criteria
Who can join
- Is at least 18 or the legal age of consent in the jurisdiction in which the study is taking place, at the time of signing the informed consent.
- Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form and in the protocol.
- NDMM with a requirement for treatment as documented per IMWG criteria.
- Must have at least 1 aspect of measurable disease, as assessed by the central laboratory, defined as 1 of the following:
- Urine M-protein excretion ≥200 mg/24 hours (≥0.2 g/24 hours) And/or
- Serum M-protein concentration ≥0.5 g/dL (≥5.0 g/L) And/or
- Serum free light-chain (FLC) assay: involved FLC level ≥10 mg/dL (≥100 mg/L) and an abnormal serum FLC ratio (\ 1.65).
- Newly diagnosed and not considered candidate for high-dose chemotherapy with autologous stem cell transplant (ASCT) due to any of the following:
- Exclusion from treatment with ASCT due to country- or site-specific age restriction.
- Presence of comorbid condition(s) likely to have a negative impact on side effects of high-dose chemotherapy with ASCT.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2.
- Adequate organ system function as defined by the laboratory assessments.
- Male participants:
- Contraceptive use by men should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.
- Male participants are eligible to participate if they agree to the following during the Treatment Period and for at least 6 months after the last dose of study intervention to allow for clearance of any altered sperm:
- Refrain from donating fresh unwashed semen PLUS either:
- Be abstinent from heterosexual intercourse as their preferred and usual lifestyle (abstinent on a long term and persistent basis) and agree to remain abstinent. OR
- Must agree to use contraception/barrier as detailed below
- Agree to use a male condom, even if they have undergone a successful vasectomy, and female partner to use an additional highly effective contraceptive method with a failure rate of \<1% per year when having sexual...
- Female participants
- Contraceptive use by women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.
- A female participant is eligible to participate if she is not pregnant or breastfeeding, and at least 1 of the following conditions applies:
- Is not a WOCBP OR
- Is a WOCBP and using a contraceptive method that is highly effective (with a failure rate of \<1% per year), preferably with low user dependency during the Treatment Period and for 4 months after the last dose of study...
- A WOCBP must have 2 negative highly sensitive serum pregnancy tests before starting treatment, the first may be performed within 14 days from C1D1, the second within 24 hours before the first dose of study intervention.
- Should pregnancy occur in a female on treatment or the female partner of a male on treatment, treatment must be stopped, and it is advised to seek advice from a physician specialized or experienced in teratology.
What rules you out
- Diagnosis of systemic amyloid light chain amyloidosis, Waldenstrom's disease, POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma proliferative disorder, skin changes) or Primary Plasma Cell Leukemia...
- Prior systemic therapy for multiple myeloma, or smoldering multiple myeloma.
- Signs of meningeal or central nervous system involvement with multiple myeloma.
- Major surgery within 2 weeks prior to the first dose of study drugs or has not recovered fully from surgery. Kyphoplasty is not considered major surgery.
- Any serious and/or unstable pre-existing medical, psychiatric disorder or other conditions (including lab abnormalities) that could interfere with participant's safety, obtaining informed consent, or compliance with...
- Current active liver or biliary disease (except for Gilbert's syndrome or asymptomatic gallstones, or otherwise stable chronic liver disease as per the investigator's assessment).
- Participants with previous or concurrent malignancies other than multiple myeloma are excluded. Exceptions are any other malignancy that has been considered medically stable for at least 2 years, after discussion with...
- Evidence of cardiovascular risk including any of the following:
- Evidence of current clinically significant untreated arrhythmias, including clinically significant electrocardiogram abnormalities including second-degree (Mobitz Type II) or third-degree atrioventricular block.
- Recent history (within 3 months of screening) of myocardial infarction, acute coronary syndromes (including unstable angina), coronary angioplasty or stenting, or bypass grafting.
- Class III or IV heart failure as defined by the New York Heart Association functional classification system.
- Known human immunodeficiency virus (HIV) infection, unless the participant can meet all of the following criteria:
- Established antiretroviral therapy for at least 4 weeks and HIV viral load \<400 copies/mL within Screening Period.
- CD4+ T-cell (CD4+) counts ≥350 cells/μL.
- No history of acquired immune deficiency syndrome-defining opportunistic infections within the last 12 months.
- Positive hepatitis C antibody test result or positive hepatitis C ribonucleic acid (RNA) test result at screening or within 3 months prior to first dose of study intervention unless the participant can meet the...
- RNA test negative.
- Successful antiviral treatment (usually 8 weeks duration) is required, followed by a negative hepatitis C viral load RNA test after a washout period of at least 4 weeks.
- Participants with hepatitis B will be excluded unless the defined criteria can be met.
- Current corneal epithelial disease except for mild punctate keratopathy.
- Intolerance or contraindications to antiviral prophylaxis.
- Unable to tolerate antithrombotic prophylaxis.
- Known immediate or delayed hypersensitivity reaction or idiosyncratic reaction to drugs chemically related to belantamab mafodotin, or any of the components of the study intervention.
- Plasmapheresis within 7 days prior to the first dose of study intervention.
- Participants must not have received a live or live-attenuated vaccine within 30 days prior to first dose of belantamab mafodotin.
The study team makes the final eligibility decision.
Where it's taking place
- Mobile, Alabama, United States
- Phoenix, Arizona, United States
- Beverly Hills, California, United States
- Pasadena, California, United States
- Aurora, Colorado, United States
- Washington D.C., District of Columbia, United States
- Englewood, Florida, United States
- Lady Lake, Florida, United States
- Pembroke Pines, Florida, United States
- Saint Augustine, Florida, United States
- Atlanta, Georgia, United States
- Portland, Maine, United States
- Worcester, Massachusetts, United States
- Ann Arbor, Michigan, United States
- Detroit, Michigan, United States
- Billings, Montana, United States
- Hackensack, New Jersey, United States
- New York, New York, United States
- Stony Brook, New York, United States
- Charlotte, North Carolina, United States
+ 142 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Mobile, Alabama, United States; Phoenix, Arizona, United States; Beverly Hills, California, United States; Pasadena, California, United States; Aurora, Colorado, United States; Washington D.C., District of Columbia, United States and 156 more location(s). Enter your location above to see the nearest site and check your eligibility.
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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.