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New treatment option for Healthy
Official title Intermittent Fasting on the Blood Microbiome
ClinicalTrials.gov ID: NCT06678516
What this study is testing
- What it's testing
- The investigators previously demonstrated that the gut microbiome can be remodeled by one month of intermittent fasting (OMIF) in healthy volunteers and animal models, with a notable alteration observed in its overall composition which could be linked to improvement in liver function. The blood microbiome, which mirrors the human ecosystem and includes all microbes mainly including bacteria, archaea, and viruses, is a new-identified human microbiome assessment tool that is assumed to be more stable and representative than the gut microbiome, with substantial potential for the diagnosis and prediction of liver cirrhosis and cancer.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65. Healthy volunteers may be eligible.
You may be able to join if
- Age 18-65 years
- 18.5 =\< BMI \< 25 kg/m2
- All genders are included.
- Have not fasted (go for a day without any food) for any amount of days in the month before the start of the study
- Being willing to provide App-derived movement data over the course of the study
You likely can't join if
- Regular use medications such as antibiotics, steroids, beta blockers, and adrenergic-stimulating agents (self-report)
- Regular use prebiotic and/or probiotics (self-report)
- Intake of antibiotic at least in previous 1 months (self-report)
- Daily consumption of \>10 cigarettes, or \>6 cups of coffee (the latter because of the effects on circadian rhythm). (self-report)
- Chronic diseases including type 2 diabetes, hypertension, fatty liver disease, cancer, or autoimmune disease (self-report and clinical chemistry)
- Internal diseases, including those of the gastrointestinal tract, lung, heart, vasculature, liver, and kidney (self-report and clinical chemistry)
See the full eligibility criteria
- Age 18-65 years
- 18.5 =\< BMI \< 25 kg/m2
- All genders are included.
- Have not fasted (go for a day without any food) for any amount of days in the month before the start of the study
- Being willing to provide App-derived movement data over the course of the study
- Participants are willing to and capable of providing written informed consent.
- Regular use medications such as antibiotics, steroids, beta blockers, and adrenergic-stimulating agents (self-report)
- Regular use prebiotic and/or probiotics (self-report)
- Intake of antibiotic at least in previous 1 months (self-report)
- Daily consumption of \>10 cigarettes, or \>6 cups of coffee (the latter because of the effects on circadian rhythm). (self-report)
- Chronic diseases including type 2 diabetes, hypertension, fatty liver disease, cancer, or autoimmune disease (self-report and clinical chemistry)
- Internal diseases, including those of the gastrointestinal tract, lung, heart, vasculature, liver, and kidney (self-report and clinical chemistry)
- Eating disorder or unconventional eating habits (self-report)
- Have a clinically significant abnormality as measured by a blood test
- Participation in another study (self-report)
- Habit of performing regular fasting (self-report)
- Women: pregnancy and breastfeeding (self-report)
The study team makes the final eligibility decision.
Where it's taking place
- Lanzhou, Gansu, China
- Rotterdam, Netherlands
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Lanzhou, Gansu, China; Rotterdam, Netherlands. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.