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Tests treatment safety and results for Atelectasis
Official title Physiological Effects and Safety of Continuous High-frequency Oscillatory Ventilation in Mechanical Ventilation Patients
ClinicalTrials.gov ID: NCT06662630
What this study is testing
- What it's testing
- Mechanical ventilation is an important treatment modality for intensive care unit (ICU) patients, but it also brings a series of problems such as ventilator-associated pneumonia, ventilator-induced lung injury, and atelectasis. Continuous High-Frequency Oscillation (CHFO )is often considered to have a protective effect on the lungs.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 20 to 90
You may be able to join if
- Patients older than 18 and younger than 90 years;
- Admitted to the ICU after October 15, 2024, who are intubated and expected to be unable to be extubated within 48 hours due to ARDS, or have...
- Signed informed consent for MetaNeb treatment.
You likely can't join if
- Refusal to participate in the proposed study.
- Age \< 20 years;
- Pregnancy;
- Significant hemodynamic instability defined as an increase of more than 20% in catecholamine doses in the last hour, despite optimization of blood...
- Participation in another trial within 30 days prior to meeting eligibility criteria;
- Severe chronic respiratory disease requiring long-term oxygen therapy or home mechanical ventilation;
See the full eligibility criteria
- Patients older than 18 and younger than 90 years;
- Admitted to the ICU after October 15, 2024, who are intubated and expected to be unable to be extubated within 48 hours due to ARDS, or have atelectasis, or have VAP.
- Signed informed consent for MetaNeb treatment.
- Refusal to participate in the proposed study.
- Age \< 20 years;
- Pregnancy;
- Significant hemodynamic instability defined as an increase of more than 20% in catecholamine doses in the last hour, despite optimization of blood volume, for a target mean blood pressure between 65 and 75 mmHg.
- Participation in another trial within 30 days prior to meeting eligibility criteria;
- Severe chronic respiratory disease requiring long-term oxygen therapy or home mechanical ventilation;
- Pneumothorax;
- Expected duration of mechanical ventilation \< 48 hours
- Decision to refuse life-sustaining treatment.
The study team makes the final eligibility decision.
Where it's taking place
- Shanghai, Shanghai Municipality, China
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 20 years to 90 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Shanghai, Shanghai Municipality, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.