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New treatment option for Von Willebrand Disease (VWD)
Official title Algorithm-based Management to Reduce the Recurrence of GI Bleeding and Severe Epistaxis in Von Willebrand Disease
ClinicalTrials.gov ID: NCT06651255
What this study is testing
- What it's testing
- WILL MANAGE is a prospective multicenter controlled open label randomized trial comparing an algorithm-based multidisciplinary management to a standard of care to reduce the incidence of bleeding (GI bleeding or severe epistaxis) recurrence in von Willebrand disease.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Males and females adults aged \> 18 years
- With a constitutional von Willebrand Disease (according to the phenotypic criteria of the French Reference Center of von Willebrand Disease)
- With a GI bleeding [either overt (any hematemesis, any melena or hematochezia with at least a 2g/dL drop in hemoglobin) or occult (iron deficiency...
- Be affiliated to a social security scheme
- Written informed consent obtained
You likely can't join if
- Acquired von Willebrand Disease
- Presence of an inhibitor to VWF or a contra indication to VWF concentrates
- Contra-indication to videocapsule endoscopy
- Refusal of the procedures part of the study
- Pregnant women or breastfeeding
- Short-life expectancy
See the full eligibility criteria
- Males and females adults aged \> 18 years
- With a constitutional von Willebrand Disease (according to the phenotypic criteria of the French Reference Center of von Willebrand Disease)
- With a GI bleeding [either overt (any hematemesis, any melena or hematochezia with at least a 2g/dL drop in hemoglobin) or occult (iron deficiency anemia with at least 2g/dL drop in hemoglobin)] with the presence of...
- Be affiliated to a social security scheme
- Written informed consent obtained
- Acquired von Willebrand Disease
- Presence of an inhibitor to VWF or a contra indication to VWF concentrates
- Contra-indication to videocapsule endoscopy
- Refusal of the procedures part of the study
- Pregnant women or breastfeeding
- Short-life expectancy
- Liver cirrhosis Child-Pugh C or diagnosed portal hypertension
- Cancer currently undergoing chemotherapy
- Inability to provide informed consent
- Patient under justice protection
The study team makes the final eligibility decision.
Where it's taking place
- Lille, Nord, France
- Tours, Tours, France
- Amiens, France
- Brest, France
- Bron, France
- Caen, France
- Chambéry, France
- Clermont-Ferrand, France
- Dijon, France
- Le Kremlin-Bicêtre, France
- Marseille, France
- Montpellier, France
- Nantes, France
- Rennes, France
- Rouen, France
- Strasbourg, France
- Toulouse, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Lille, Nord, France; Tours, Tours, France; Amiens, France; Brest, France; Bron, France; Caen, France and 11 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.