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New treatment option for THC
Official title Pilot fMRI Studies of Aging-Related Effects of THC
ClinicalTrials.gov ID: NCT06647524
What this study is testing
What is THC?
THC is an investigational medicine, being studied as a potential treatment for thc.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to begin investigating acute impairment of various forms of memory and learning by Tetrahydrocannabinol (THC) in cannabis (CNB) compared to placebo, in a 2-session per subject double-blind, random assignment, placebo-controlled counterbalanced design in young to middle-aged adults.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75
You may be able to join if
- CNB use within past 2 years and felt "high" when used.
- Able to read, speak, and understand English.
- Able and willing to provide written informed consent, and willing to commit to the study protocol.
You likely can't join if
- Current marijuana tolerance, desire to cut down, or cravings to use during periods of abstinence.
- Positive screen for drug or alcohol (except CNB) on test day will result in rescheduling the appointment
- History of adverse effects with CNB
- CNB users who are abstaining
- IQ \<80 on the Wechsler Abbreviated Scale of Intelligence
- Inability to comprehend written instructions using the WRAT 4 reading achievement test
See the full eligibility criteria
- CNB use within past 2 years and felt "high" when used.
- Able to read, speak, and understand English.
- Able and willing to provide written informed consent, and willing to commit to the study protocol.
- Current marijuana tolerance, desire to cut down, or cravings to use during periods of abstinence.
- Positive screen for drug or alcohol (except CNB) on test day will result in rescheduling the appointment
- History of adverse effects with CNB
- CNB users who are abstaining
- IQ \<80 on the Wechsler Abbreviated Scale of Intelligence
- Inability to comprehend written instructions using the WRAT 4 reading achievement test
- Pregnant, breastfeeding, and ineffective birth control methods
- Unable or unsafe to have an MRI
- Serious medical, neuro-ophthalmological, or neurological illness (e.g. cancer, seizure disorders, encephalopathy
- History of head trauma with loss of consciousness \> 30 minutes or concussion lasting 30 days
- Focal brain lesion seen on structural MRI
- Any medical/neurological condition that could compromise neurocognitive performance (e.g. epilepsy, multiple sclerosis, fetal alcohol syndrome)
- Anyone deemed unsafe to study personnel for any reason
- Hearing loss such that subject cannot hear sounds at the levels (dB) or pitches (Hz) to be used in the study
- Significant pain and/or reduced mobility in the arms
The study team makes the final eligibility decision.
Where it's taking place
- Hartford, Connecticut, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Hartford, Connecticut, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.