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New treatment option for Leukemia
Official title Venetoclax Combined with Intensive Therapy for Acute Myeloid Leukemia Patients with Lower Early Peripheral Blast Clearance Rate After Standard Induction Therapy
ClinicalTrials.gov ID: NCT06643962
What this study is testing
What is Venetoclax?
Venetoclax is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for leukemia.
Also referred to as Bcl-2 inhibitors.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This single-center prospective cohort study aims to evaluate the efficacy and safety of Intensifying treatment with Venetoclax along with intensive chemotherapy in patients with newly diagnosed acute myeloid leukemia (AML) except acute promyelocytic leukemia (non-APL) and exhibiting lower early peripheral blast clearance rate (EPBCR) after standard Intensive Induction therapy (3+7 regimen).
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70
You may be able to join if
- Newly diagnosed AML, except for the APL subtype, according to the 2022 World Health Organization classification (WHO 2022 criteria)
- Age ≥18 years and ≤70 years
- Eligible for intensive chemotherapy
- No prior chemotherapy for AML except hydroxyurea for up to 14 days during the diagnostic screening phase for the control of peripheral leukemic...
- Eastern Cooperative Oncology Group (ECOG) performance status≤2
You likely can't join if
- AML with BCR-ABL1 or myeloid blast crisis of CML
- Participants who have received prior treatment for AML with chemotherapy, hypomethylating agents, or venetoclax
- Participants who are ineligible for intensive induction chemotherapy:
- ≧71 years old OR
- ≧18 to 70 years old and fulfill at least one criterion associated with lack of fitness for intensive induction chemotherapy:
- ECOG PS of 2-3
See the full eligibility criteria
- Newly diagnosed AML, except for the APL subtype, according to the 2022 World Health Organization classification (WHO 2022 criteria)
- Age ≥18 years and ≤70 years
- Eligible for intensive chemotherapy
- No prior chemotherapy for AML except hydroxyurea for up to 14 days during the diagnostic screening phase for the control of peripheral leukemic blasts in patients with leukocytosis (e.g., white blood cell [WBC]...
- Eastern Cooperative Oncology Group (ECOG) performance status≤2
- Adequate renal function is defined as:
- Serum creatinine≤2.0×upper limit of normal (ULN)
- Creatinine clearance (CrCl)\>30 mL/min calculated by the Cockcroft-Gault equation.
- Adequate hepatic and heart function is defined as:
- Serum total bilirubin≤1.5×ULN unless considered due to Gilbert's disease, or leukemic involvement
- Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP)≤2.5×ULN, unless considered due to leukemic involvement
- Myocardial enzyme\<2.0×ULN
- Left ventricular ejection fraction is within the normal range by measure of echocardiogram (ECHO)
- Signed a written informed consent form (ICF)
- Female participants who are of non-reproductive potential (i.e., post-menopausal by history of no menses for ≥1 year; OR history of hysterectomy; OR history of bilateral tubal ligation; OR history of bilateral...
- AML with BCR-ABL1 or myeloid blast crisis of CML
- Participants who have received prior treatment for AML with chemotherapy, hypomethylating agents, or venetoclax
- Participants who are ineligible for intensive induction chemotherapy:
- ≧71 years old OR
- ≧18 to 70 years old and fulfill at least one criterion associated with lack of fitness for intensive induction chemotherapy:
- ECOG PS of 2-3
- Cardiac history of CHF requiring treatment or Ejection Fraction ≦50% or chronic stable angina
- Diffusing capacity of the lungs for carbon monoxide (DLCO)≦65% or the forced expiratory volume in one second (FEVI) ≦65%
- Participants with a prior history of MDS, MPN, or MDS/MPN
- Participants with other concurrent malignant tumors on treatment, except for:
- Malignancy treated with curative intent and with no known active disease present for ≧3 years
- Adequately treated non-melanoma skin cancer or lentigo maligna without current evidence of disease
- Adequately treated carcinoma in situ without current evidence of disease
- Localized prostate cancer with a Gleason score of 6 or less
- Pregnant or lactating women
- Active heart disease is defined as any one of the following:
- Uncontrolled or symptomatic angina pectoris
- A myocardial infarction six months before enrolled
- Arrhythmia needs medication or with severe clinical symptoms
- Uncontrolled or symptomatic congestive heart failure (New York Hear Association [NYHA] classification\> grade 2)
- Participants with an active, uncontrolled, systemic fungal, bacterial, or viral infection without improvement despite appropriate antibiotics, antiviral therapy, and/or other treatment
- Participants with an active viral infection caused by HIV, hepatitis B, or hepatitis C virus that cannot be controlled by treatment
- Participants with evidence of central nervous system leukemia before the study treatment
- Participants with epilepsy which needs drug treatment, dementia, or other abnormal mental states that prevent understanding or following the protocol
- Conditions that restrict the intake or absorption of orally administered drugs
The study team makes the final eligibility decision.
Where it's taking place
- Nantong, Jiangsu, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Nantong, Jiangsu, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.