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New treatment option for Opioid Use Disorder
Official title Integrated Treatment for Opioid Use Disorder and PTSD
ClinicalTrials.gov ID: NCT06641115
What this study is testing
- What it's testing
- This study will test a therapy intervention, HOPE, for individuals with opioid use disorder and posttraumatic stress disorder. Interested individuals will need to be taking medications for opioid use disorder (e.g., suboxone, naltrexone, methadone).
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70
You may be able to join if
- Any gender; any race or ethnicity; aged 18-70 years old.
- English-speaking
- Meet DSM-5 diagnostic criteria for OUD.
- Meet DSM-5 diagnostic criteria for PTSD and have some memory of their index traumatic event.
- Must be maintained on a stable dose of medication for OUD for at least 1 month.
You likely can't join if
- Participants presenting with psychiatric contraindications (e.g., unmanaged psychosis or mania, or bipolar) will be excluded and referred clinically.
- Participants considered an immediate suicide risk, with current suicidal ideation and a plan of intent, or displaying other high-risk behaviors...
- Participants meeting DSM-5 criteria for a concurrent, non-opioid, substance use disorder and who report that the other substance is their primary...
- Participants enrolled in ongoing evidence-based psychotherapy for substance use disorders or PTSD outside of medications for OUD and standard...
- Medical problems requiring immediate and intensive treatment, such as unstable or symptomatic end stage liver disease.
See the full eligibility criteria
- Any gender; any race or ethnicity; aged 18-70 years old.
- English-speaking
- Meet DSM-5 diagnostic criteria for OUD.
- Meet DSM-5 diagnostic criteria for PTSD and have some memory of their index traumatic event.
- Must be maintained on a stable dose of medication for OUD for at least 1 month.
- Participants taking psychotropic medications will be required to be maintained on a stable dose for at least 1 month before study initiation.
- Participants presenting with psychiatric contraindications (e.g., unmanaged psychosis or mania, or bipolar) will be excluded and referred clinically.
- Participants considered an immediate suicide risk, with current suicidal ideation and a plan of intent, or displaying other high-risk behaviors (i.e., MOUD refusal, risky fentanyl use, etc.), as determined by the PI and...
- Participants meeting DSM-5 criteria for a concurrent, non-opioid, substance use disorder and who report that the other substance is their primary substance of use. These participants will be referred clinically for...
- Participants enrolled in ongoing evidence-based psychotherapy for substance use disorders or PTSD outside of medications for OUD and standard psychotherapy groups in treatment programs.
- Medical problems requiring immediate and intensive treatment, such as unstable or symptomatic end stage liver disease.
The study team makes the final eligibility decision.
Where it's taking place
- Charleston, South Carolina, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Charleston, South Carolina, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.