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New treatment option for Emotional Processing
Official title Losartan and Emotional Processing in Young People
ClinicalTrials.gov ID: NCT06636812
What this study is testing
What is Losartan potassium?
Losartan potassium is an investigational medicine, being studied as a potential treatment for emotional processing.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study explores the effects of single-dose losartan (50mg) versus placebo on emotional processing in young healthy volunteers.
- Phase 1: an early, usually small safety study
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 16 to 20. Healthy volunteers may be eligible.
You may be able to join if
- Willing and able to provide informed consent (for 16 and 17 year olds: assent and parental/ legal guardian consent)
- Non- or light-smoker (\< 5 cigarettes a day)
- Ability to attend appointments in Oxford with reasonable travel costs
- Ability/ willingness to provide GP contact details
You likely can't join if
- Past or present DSM-5 axis-I diagnosis (based on SCID results at screening), especially severe psychiatric illness or alcohol or substance dependence
- First-degree family member with severe psychiatric illness
- CNS-medication last 6 weeks (including as part of another study)
- Current blood pressure or other heart medication (especially aliskiren or beta blockers)
- Diagnosis of intravascular fluid depletion or dehydration
- Impaired kidney function (based on blood test at screening, cut-off 75 ml/min/1.73 m2)
See the full eligibility criteria
- Willing and able to provide informed consent (for 16 and 17 year olds: assent and parental/ legal guardian consent)
- Non- or light-smoker (\< 5 cigarettes a day)
- Ability to attend appointments in Oxford with reasonable travel costs
- Ability/ willingness to provide GP contact details
- Past or present DSM-5 axis-I diagnosis (based on SCID results at screening), especially severe psychiatric illness or alcohol or substance dependence
- First-degree family member with severe psychiatric illness
- CNS-medication last 6 weeks (including as part of another study)
- Current blood pressure or other heart medication (especially aliskiren or beta blockers)
- Diagnosis of intravascular fluid depletion or dehydration
- Impaired kidney function (based on blood test at screening, cut-off 75 ml/min/1.73 m2)
- Significant hyperkalaemia (level\>=6mEq/L in the absence of sample haemolysis will be considered significant hyperkalaemia)
- Very low blood pressure (defined as repeated (at least three consecutive measurements) measures of blood pressure under standardised conditions where either the systolic or the diastolic blood pressure or both are below...
- Body weight below 35kg (as the lower dose of 25mg of losartan only indicated from 35kg)
- Lifetime history of epilepsy or other neurological disease (e.g. ADHD, autism)
- Lifetime history of angioedema, renal artery stenosis, valvular heart disease, recurrent postural/ orthostatic hypotension
- Lifetime history ofsystemic infection, or clinically significant hepatic, cardiac, obstructive respiratory, renal, cerebrovascular, metabolic, endocrine or pulmonary disease or disorder which, in the opinion of the...
- Significant loss of hearing that is not corrected with a hearing device Insufficient written and/or spoken English skills
- Women: pregnancy, breast-feeding
The study team makes the final eligibility decision.
Where it's taking place
- Oxford, Oxfordshire, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 16 years to 20 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Oxford, Oxfordshire, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.