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New treatment option for Breast Cancer
Official title MRI-Guided Ultrasound Stimulated Microbubbles Radiation Treatment for Patients with Chest-Wall and Locally Advanced Breast Cancer
ClinicalTrials.gov ID: NCT06633601
What this study is testing
What is Definity Suspension for Injection?
Definity Suspension for Injection is an investigational medicine, being studied as a potential treatment for breast cancer.
Also referred to as Microbubbles.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The objective of this study is to demonstrate the feasibility of novel Magnetic Resonance Imaging (MRI)-guided ultrasound stimulated microbubble treatment to enhance radiation effects in humans receiving external beam radiotherapy delivered using a LINAC (linear accelerator) radiation therapy device.
- Phase 1: an early, usually small safety study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥ 18 years.
- All biopsy-confirmed invasive ductal, invasive lobular and other rare histologic types of carcinoma.
- Patients with early stage Breast cancer, or LABC ; i.e., Stage IIA - IIIC cancers (T2 N0 M0 to Any T, N3, M0) or Stage IV (Any T, Any N, M1) per AJCC...
- Assessed as indicated, by a multidisciplinary team of treating medical, surgical and radiation oncologist and found suitable for radiation treatment.
- Patient referred for standard palliative radiotherapy or curative radiotherapy, which may include (but are not limited to) any of the following dose...
You likely can't join if
- Pregnant or lactating women may not participate due to the embryotoxic effects of protocol treatment.
- Unable to have a contrast-enhanced MRI scan - standard of care criteria.
- Patients having received anthracycline or taxane based chemotherapy within the past 5 days.
- Patients with metallic or breast implants.
- people with connective tissue disorder, musculoskeletal deformity.
- Target lesion causing deep ulceration, bleeding or discharge of the overlying skin.
See the full eligibility criteria
- Age ≥ 18 years.
- All biopsy-confirmed invasive ductal, invasive lobular and other rare histologic types of carcinoma.
- Patients with early stage Breast cancer, or LABC ; i.e., Stage IIA - IIIC cancers (T2 N0 M0 to Any T, N3, M0) or Stage IV (Any T, Any N, M1) per AJCC guidelines (8th Edition).
- Assessed as indicated, by a multidisciplinary team of treating medical, surgical and radiation oncologist and found suitable for radiation treatment.
- Patient referred for standard palliative radiotherapy or curative radiotherapy, which may include (but are not limited to) any of the following dose regimens: 1) 5-8 Gy in one fraction, 2) 20 Gy in 5 fractions, 3) 30 Gy...
- Able to understand and give informed consent.
- Weight \< 140 kg.
- Target lesion accessible for MRg-FUS+MB procedure.
- Able to communicate sensation during the procedure.
- Creatinine within normal institutional limits or creatinine clearance \>60mL/min/ Novel MRI-Guided Ultrasound Stimulated Microbubble Radiation Treatment for Patients with Chest-Wall and Locally Advanced Breast Cancer...
- Pregnant or lactating women may not participate due to the embryotoxic effects of protocol treatment.
- Unable to have a contrast-enhanced MRI scan - standard of care criteria.
- Patients having received anthracycline or taxane based chemotherapy within the past 5 days.
- Patients with metallic or breast implants.
- people with connective tissue disorder, musculoskeletal deformity.
- Target lesion causing deep ulceration, bleeding or discharge of the overlying skin.
- A fibrotic scar along the proposed FUS beam path.
- Severe cardiovascular, neurological, renal or hematological chronic disease.
- Eastern Cooperative Oncology Group (ECOG) Performance Status ≥ 3.
- Any condition that in the investigator's opinion precludes participation.
- Unable to tolerate required stationary position during treatment.
- Allergy to Definity microbubbles.
- Cardiac disease or unstable hemodynamics including myocardial infarction within six months, unstable angina, congestive heart failure, cardiac shunts, cardiac arrhythmia and cardiac pacemaker.
- Contraindication to perflutren including people with a family or personal history of QT prolongation or taking concomitant medications known to cause QTc prolongation like cisapride, erythromycin, tricyclic...
- Known QT prolongation = (QTc \> 450ms for men or \>470ms for women) with cardiac impairment if ECG is requested as per SOC.
- History of bleeding disorder, coagulopathy.
- Severely impaired renal function with estimated glomerular filtration rate \< 30ml/min/1.73m2 and/or on dialysis.
The study team makes the final eligibility decision.
Where it's taking place
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Toronto, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.