BridgeMD
Prevention study for Diuretics Drug Reactions
Official title PREVENTION OF WORSENING RENAL FUNCTION OF INTRAVENUS ALBUMIN IN HEART FAILURE PATIENTS
ClinicalTrials.gov ID: NCT06630923
What this study is testing
What is Human albumin?
Human albumin is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for diuretics drug reactions.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Patients hospitalized for acute decompensation of CHF are usually complicated by worsening renal function (WRF) which leads to diuretic resistance and inadequate decongestion as well as poor prognosis. WRF has been attributed to a reflex renal vasoconstriction elicited by intravascular volume depletion during brisk diuresis.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 95
You may be able to join if
- age over 18 yrs
- acute decompensation of CHF
- evidence of hepatic dysfunction by laboratory biochemical measurements or imaging (liver ultrasonography)
- history of CHF with previous use of an oral loop diuretic
- anticipated need for IV diuretic therapy for at least 72 hours There is no pre-specified inclusion criterion with respect to ejection fraction
You likely can't join if
- hemodynamic collapse (at least one of the following: systolic blood pressure (BP) \ = 40 mmHg for \>= 15 min, with end-organ hypoperfusion; need for...
- hepatic dysfunction of other than cardiac etiology
- severe anemia (Hb\<8 g/dL)
- uncontrolled hypertension or hypertensive emergency/urgency
- pulmonary edema or pulmonary congestion necessitating use of IV vasodilators
- serum creatinine \> 3 mg/dL or glomerular filtration rate (GFR) \< 30 ml/min
The study team makes the final eligibility decision.
Where it's taking place
- Alexandroupoli, Evros, Greece
Compensation & support
Compensation likely.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 95 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Alexandroupoli, Evros, Greece. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.