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New treatment option for Bone Fractures
Official title Naringenin Supplementation in Bone Fracture Patients
ClinicalTrials.gov ID: NCT06612762
What this study is testing
- What it's testing
- Fractures of the lower extremities represent a significant proportion of injuries sustained by polytrauma patients, with a notable association with prolonged hospitalization, chronic disability, and impaired physical functioning. The occurrence of surgical site infections (SSI) represents a significant threat to the efficacy of osteosynthesis procedures.
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 60
You may be able to join if
- Candidate for orthopedic surgery for bone fractures of the lower limbs,
- Ambulatory without assistance for a minimum of two months prior to the fracture.
- Not having undergone amputation of the lower limbs.
- Not suffering from liver cirrhosis.
- Not suffering from advanced kidney failure (blood creatinine higher than 1.4 mg/dL).
You likely can't join if
- Allergy or intolerant reaction to narangenin capsules
- Any abnormal changes in their liver, kidneys tests,
- Failure to consume more than 10% of their capsules
See the full eligibility criteria
- Candidate for orthopedic surgery for bone fractures of the lower limbs,
- Ambulatory without assistance for a minimum of two months prior to the fracture.
- Not having undergone amputation of the lower limbs.
- Not suffering from liver cirrhosis.
- Not suffering from advanced kidney failure (blood creatinine higher than 1.4 mg/dL).
- Not having metastatic cancer, any chronic inflammatory diseases, nor taking any drugs that affect bone metabolism, including calcitonin, bisphosphonates, and corticosteroids.
- Allergy or intolerant reaction to narangenin capsules
- Any abnormal changes in their liver, kidneys tests,
- Failure to consume more than 10% of their capsules
The study team makes the final eligibility decision.
Where it's taking place
- Tehran, Iran
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 60 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Tehran, Iran. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.