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New treatment option for Type 1 Diabetes Mellitus
Official title Cardiometabolic Benefit of Reducing Iatrogenic Hyperinsulinemia Using Insulin Adjunctive Therapy in Type 1 Diabetes
ClinicalTrials.gov ID: NCT06609356
What this study is testing
What is Sodium Glucose Co-transporter 2 (SGLT2) Inhibitor?
Sodium Glucose Co-transporter 2 (SGLT2) Inhibitor is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for type 1 diabetes mellitus.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study aims to understand the heart and blood sugar health benefits of using an adjunctive therapy to lower high insulin levels in people with type 1 diabetes. The investigators will also look at people with a specific type of diabetes called Glucokinase-Maturity Onset Diabetes of the Young (GCK-MODY) and those without diabetes to help interpret the results.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 60. Healthy volunteers may be eligible.
You may be able to join if
- Age: 18-60 years BMI: 18-28 kg/m² Weight: ≥ 50 kg
- T1DM Participants:
- Duration of T1DM: 1-30 years HbA1c: 5.7-7.5% Insulin Therapy: Using automated insulin delivery
- GCK-MODY Participants:
- HbA1c: 5.7-7.5% Genetic Confirmation: Positive GCK sequencing
You likely can't join if
- Severe Hypoglycemia: ≥1 episode in the past 3 months Comorbidities:
- Any hospital admissions for diabetic ketoacidosis in the past 6 months
- SBP greater than 140 mmHg and DBP greater than 100 mmHg
- eGFR by MDRD equation of less than 60 mL/min/1.73 m²
- AST or ALT greater than 2.5 times ULN
- Hct less than 35% Medications:
See the full eligibility criteria
- Age: 18-60 years BMI: 18-28 kg/m² Weight: ≥ 50 kg
- T1DM Participants:
- Duration of T1DM: 1-30 years HbA1c: 5.7-7.5% Insulin Therapy: Using automated insulin delivery
- GCK-MODY Participants:
- HbA1c: 5.7-7.5% Genetic Confirmation: Positive GCK sequencing
- Control Participants:
- HbA1c: less than 5.5%
- Severe Hypoglycemia: ≥1 episode in the past 3 months Comorbidities:
- Any hospital admissions for diabetic ketoacidosis in the past 6 months
- SBP greater than 140 mmHg and DBP greater than 100 mmHg
- eGFR by MDRD equation of less than 60 mL/min/1.73 m²
- AST or ALT greater than 2.5 times ULN
- Hct less than 35% Medications:
- Any antioxidant vitamin supplement within 2 weeks before the study
- Any systemic glucocorticoid
- Antipsychotics
- Atenolol, Metoprolol, Propranolol
- Niacin
- Any thiazide diuretic
- Any oral contraceptive pill with greater than 35 mcg ethinyl estradiol
- Growth hormone
- Any immunosuppressant
- Antihypertensive
- Any antihyperlipidemic Other:
- Pregnancy
- Tanner stage less than 5
- Peri- or post-menopausal women
- Active smoker T1DM Participants: Medications: Any diabetes medication except insulin C-peptide: greater than 0.7 ng/mL (fasting) GCK-MODY Participants: None specific
The study team makes the final eligibility decision.
Where it's taking place
- Nashville, Tennessee, United States
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 60 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Nashville, Tennessee, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.