BridgeMD
New treatment option for Secondary Progressive Multiple Sclerosis (SPMS)
Official title The Effect of Rituximab on Cognitive and Hand Functions in Secondary Progressive Multiple Sclerosis
ClinicalTrials.gov ID: NCT06599307
What this study is testing
What is Rituximab?
Rituximab is an investigational medicine, being studied as a potential treatment for secondary progressive multiple sclerosis (spms).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this clinical trial is to know if rituximab can improve cognitive and hand functions in secondary progressive multiple sclerosis (SPMS) patients with high disability (EDSS 6.5 or more). The main questions it aims to answer are: Can rituximab improve cognitive and hand functions in SPMS patients?
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Diagnosis of secondary progressive multiple sclerosis by Lorscheider et al's criteria (disability progression by 1 EDSS step in patients with EDSS ≤...
- Baseline EDSS ≥ 6.5.
You likely can't join if
- Patients received disease modifying therapy for SPMS other than rituximab.
- Clinical relapse in the last 3 months before recruitment.
- Patients with documented hypersensitivity or contraindication to rituximab.
- Patients with concomitant neurologic conditions that may affect cognitive or hand functions.
The study team makes the final eligibility decision.
Where it's taking place
- Giza, Giza Governorate, Egypt
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Giza, Giza Governorate, Egypt. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.