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New treatment option for Coronary Microvascular Dysfunction
Official title Insulin Resistance and Coronary Microvascular Dysfunction in Patients with Myocardial Ischemia and Non-obstructive Coronary Artery Disease
ClinicalTrials.gov ID: NCT06597851
What this study is testing
- What it's testing
- The goal of this prospective study is to assess the correlation between coronary microvascular disfunction and insulin resistance in patients with INOCA. Patients with ANOCA and without diabetes will undergo invasive coronary microvascular assessment through coronary angiography and insulin resistance assessment through hyperinsulinemic-euglycemic clamp test.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Aged over 18 years.
- Cardiac chest pain with evidence of myocardial ischemia at noninvasive myocardial stress imaging and clinical indication to diagnostic coronary...
- Willing and able to give informed consent for participation in the study
You likely can't join if
- Obstructive CAD (defined as more than 70% luminal stenosis and/or FFR ≤0.80 in 1 or more epicardial vessels).
- History of previous myocardial infarction, percutaneous revascularization or coronary-aortic bypass graft (CABG) surgery.
- Diagnosis of type II diabetes.
- BMI ≥ 35 kg/m2.
- Stage IV and V of chronic kidney disease (eGFR ≤ 30 ml/min, estimated through CKD - EPI Creatinine Equation).
- Allergy or other contraindication to iodinated contrast and/or gadolinium and/or adenosine.
See the full eligibility criteria
- Aged over 18 years.
- Cardiac chest pain with evidence of myocardial ischemia at noninvasive myocardial stress imaging and clinical indication to diagnostic coronary angiography
- Willing and able to give informed consent for participation in the study
- Obstructive CAD (defined as more than 70% luminal stenosis and/or FFR ≤0.80 in 1 or more epicardial vessels).
- History of previous myocardial infarction, percutaneous revascularization or coronary-aortic bypass graft (CABG) surgery.
- Diagnosis of type II diabetes.
- BMI ≥ 35 kg/m2.
- Stage IV and V of chronic kidney disease (eGFR ≤ 30 ml/min, estimated through CKD - EPI Creatinine Equation).
- Allergy or other contraindication to iodinated contrast and/or gadolinium and/or adenosine.
- Chronic resting O2 saturation ≤ 85%.
- Pregnancy or suspected pregnancy.
The study team makes the final eligibility decision.
Where it's taking place
- Verona, VR, Italy
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Verona, VR, Italy. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.