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New treatment option for Cerebral Venous Sinus Thrombosis
Official title Endovascular Treatment or Standard Medical Care for Cerebral Venous Sinus Thrombosis(ESCORT)
ClinicalTrials.gov ID: NCT06583889
What this study is testing
What is Heparin?
Heparin is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for cerebral venous sinus thrombosis.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Background: It has not been extensively studied in differing populations that endovascular treatment (EVT) for acute and subacute CVST with multimodal imaging selection improves the functional outcome better than standard medical care based on the guidelines. Published experience with endovascular treatment is promising.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 60
You may be able to join if
- General 1. age between 18 years and 60 years
- Cerebral venous sinus thrombosis (CVST), confirmed by computed tomographic and magnetic resonance imaging (T1, T2, SWI, DWI, FLAIR), magnetic...
- Patients with CVST who meet the following conditions (1) Within 3 weeks of acute onset (2) There are one of the obvious clinical symptoms: A...
- Lumbar puncture pressure≥250mmH2O
- Patients or their relatives can sign written informed consent Image 1.CT and MRI (T1, T2, MRV, SWI, DWI) are used to screen CVST as acute phase (T1...
You likely can't join if
- Received any thrombolytic therapy within 7 days
- Patients who cannot cooperate or accept MRI examination
- Patients with dementia or mental illness are known to be unable to complete neurological function assessment and follow-up
- Patients with high myopia and eye diseases affecting fundus examination and visual field examination
- The patient has a clear history of primary headache such as migraine, tension headache and cluster headache, and a clear history of secondary headache
- Patients who receive major surgery (excluding lumbar puncture) or a history of severe brain injury within 2 weeks
See the full eligibility criteria
- General 1. age between 18 years and 60 years
- Cerebral venous sinus thrombosis (CVST), confirmed by computed tomographic and magnetic resonance imaging (T1, T2, SWI, DWI, FLAIR), magnetic resonance venography, computed tomographic venography or digital subtraction...
- Patients with CVST who meet the following conditions (1) Within 3 weeks of acute onset (2) There are one of the obvious clinical symptoms: A. symptoms of intracranial hypertension: headache, papilledema, visual acuity...
- Lumbar puncture pressure≥250mmH2O
- Patients or their relatives can sign written informed consent Image 1.CT and MRI (T1, T2, MRV, SWI, DWI) are used to screen CVST as acute phase (T1 low signal, T2 equal signal or slightly high signal; CT showed that the...
- complete thrombosis of the bilateral transverse sinus with or without the corresponding sigmoid sinus involvement
- complete thrombosis of the superior transverse sinus with or without the corresponding sigmoid sinus involvement C.complete thrombosis of the superior sagittal sinus and unilateral transverse sinus with or without the...
- Received any thrombolytic therapy within 7 days
- Patients who cannot cooperate or accept MRI examination
- Patients with dementia or mental illness are known to be unable to complete neurological function assessment and follow-up
- Patients with high myopia and eye diseases affecting fundus examination and visual field examination
- The patient has a clear history of primary headache such as migraine, tension headache and cluster headache, and a clear history of secondary headache
- Patients who receive major surgery (excluding lumbar puncture) or a history of severe brain injury within 2 weeks
- Known history of severe allergy to contrast media (excluding rash)
- Gastrointestinal bleeding occurred within 3 months (excluding bleeding from recto anal hemorrhoids)
- Serious liver function or renal dysfunction with written records and affecting normal coagulation function
- Hemorrhagic disease (hemorrhagic disease history) with written records
- Excepting for CVST, patients with any life expectancy less than 1 year (such as advanced cancer)
- Pregnant women (puerperal women can be enrolled)
- Patients with contraindications to anticoagulation or thrombolysis
- Intracranial infectious or malignant tumor secondary to cerebrospinal fluid
- CVST secondary to autoimmune diseases and hematological diseases (such as primary thrombocytosis, myelodysplastic syndrome, leukemia, etc.) and genetic factors
- Concurrent thrombocytopenia (\<100×109/L)
- MRI features showed that the occluded vessels of venous sinus were in chronic phase (T1 and T2 images showed equal signal)
- Severe brain tissue injury symptoms such as obvious space occupying effect due to massive cerebral edema, cerebral infarction or cerebral hemorrhage
- Patients with CVST accompanied by ventricular compression and hydrocephalus requiring surgery
- Participating in clinical trials of any other drugs or medical devices, or may participate in clinical trials of any other drugs or medical devices within 6 months after being enrolled in this clinical trial
- The researchers judge that there are other situations that are not suitable for enrollment
The study team makes the final eligibility decision.
Where it's taking place
- Beijing, Beijing Municipality, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 60 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Beijing, Beijing Municipality, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.