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New treatment option for Critical Illness
Official title End-Tidal Oxygen for Intubation in the Emergency Department
ClinicalTrials.gov ID: NCT06578468
What this study is testing
- What it's testing
- Rapid Sequence Intubation (RSI) is a high-risk procedure in the emergency department (ED). Patients are routinely preoxygenated (given supplemental oxygen) prior to RSI to prevent hypoxia during intubation.
- This is a blinded study.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- The patient is located in the ED resuscitation bay of the participating centre.
- The planned procedure is orotracheal intubation using a laryngoscope and RSI technique with preoxygenation for patients who are spontaneously...
- The patient is deemed to be at a high risk of hypoxia during RSI as per the treating ED clinician, as defined by:
- Any patient requiring any form of oxygen therapy before preoxygenation.
- Any patient with respiratory pathology based on clinical or radiological findings. Including, but not limited to:
You likely can't join if
- Patient is known to be less than 18 years old.
- The patient has a supraglottic device in-situ e.g iGel or LMA.
- The patient is known to be pregnant.
- The patient is known to be a prisoner.
- The patient was intubated in the prehospital environment.
- Immediate need for tracheal intubation precludes preoxygenation i.e. the patient is in cardiac arrest.
See the full eligibility criteria
- The patient is located in the ED resuscitation bay of the participating centre.
- The planned procedure is orotracheal intubation using a laryngoscope and RSI technique with preoxygenation for patients who are spontaneously breathing.
- The patient is deemed to be at a high risk of hypoxia during RSI as per the treating ED clinician, as defined by:
- Any patient requiring any form of oxygen therapy before preoxygenation.
- Any patient with respiratory pathology based on clinical or radiological findings. Including, but not limited to:
- Pneumonia, pulmonary oedema, acute respiratory distress syndrome (ARDS), aspiration, pulmonary contusion from trauma, infective exacerbations of known lung disease (e.g. asthma, pulmonary fibrosis, emphysema) or...
- Any patient with high oxygen consumption. Including, but not limited to:
- Sepsis, Diabetic ketoacidosis, alcohol or drug withdrawal, seizures, thyrotoxicosis
- Any underlying patient condition that may predispose to hypoxemia. Including, but not limited to:
- Obesity, pregnancy, underlying lung disease (e.g. asthma, pulmonary fibrosis, emphysema), severe injury- hypovolaemia/haemorrhage.
- or any other patient that the treating clinician has a high concern for hypoxemia during RSI.
- Patient is known to be less than 18 years old.
- The patient has a supraglottic device in-situ e.g iGel or LMA.
- The patient is known to be pregnant.
- The patient is known to be a prisoner.
- The patient was intubated in the prehospital environment.
- Immediate need for tracheal intubation precludes preoxygenation i.e. the patient is in cardiac arrest.
The study team makes the final eligibility decision.
Where it's taking place
- Minneapolis, Minnesota, United States
- Albuquerque, New Mexico, United States
- The Bronx, New York, United States
- Sydney, New South Wales, Australia
- Melbourne, Victoria, Australia
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Minneapolis, Minnesota, United States; Albuquerque, New Mexico, United States; The Bronx, New York, United States; Sydney, New South Wales, Australia; Melbourne, Victoria, Australia. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.