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New treatment option for Chronic Coronary Syndrome
Official title Hyperemic mYocardial Perfusion by adEnosine at diffeRent Doses
ClinicalTrials.gov ID: NCT06578234
What this study is testing
What is Adenosine?
Adenosine is an investigational medicine, being studied as a potential treatment for chronic coronary syndrome.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Adenosine is a commonly used pharmaceutical stressor at cardiac magnetic resonance examinations to assess suspected chronic coronary syndrome (CCS). However, several studies have reported that the current use of adenosine does not induce adequate hyperemic response in a substantial number of patients, leading to false diagnostics.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 and older. Healthy volunteers may be eligible.
You may be able to join if
- Patients:
- The subject has given their written consent to participate in the trial.
- Are referred to Department of Clinical Physiology, Skåne University Hospital, for suspected or known CCS or heart failure
- Matches the for sex and age (6 females and 6 males from each group in each age decade from 40 to \>80 years old)
- Matches the for no known heart failure (group b) or known heart failure (group c)
You likely can't join if
- Patients:
- Acute referral (in-house patients)
- Clinically unstable
- Acute chest pain
- Severe or decompensated heart failure
- Non sinus rhythm (e.g. atrial fibrillation)
See the full eligibility criteria
- Patients:
- The subject has given their written consent to participate in the trial.
- Are referred to Department of Clinical Physiology, Skåne University Hospital, for suspected or known CCS or heart failure
- Matches the for sex and age (6 females and 6 males from each group in each age decade from 40 to \>80 years old)
- Matches the for no known heart failure (group b) or known heart failure (group c)
- No caffein intake \<24h prior to the examination Healthy volunteers:
- The subject has given their written consent to participate in the trial.
- Matches the for sex and age (6 females and 6 males from each group in each age decade from 40 to \>80 years old)
- No caffein intake \<24h prior to the examination
- Patients:
- Acute referral (in-house patients)
- Clinically unstable
- Acute chest pain
- Severe or decompensated heart failure
- Non sinus rhythm (e.g. atrial fibrillation)
- Asthma or severe chronic obstructive pulmonary disease
- Known chronic renal failure (eGFR \<45mL/min/1.73m2)
- AV-block II or III
- Left Bundle Branch Block
- Systolic blood pressure \ 230 mmHg at rest
- Increased intracranial pressure
- Known allergy or adverse reaction to adenosine or mannitol
- Known allergy or adverse reaction to gadolinium contrast agents
- Treatment with medication containing dipyradimol or teofyllamin/teofyllin
- Claustrophobia
- Devices contraindicated to CMR imaging (pacemaker, implants, intracranial clips etc)
- Pregnancy or breast feeding (screened by question only)
- Inability to give informed consent due to mental state, language difficulties etc Healthy volunteers:
- Any of the exclusion criteria for patients
- Blood pressure \> 140/90 measured according to clinical routine
- Known systemic disease
- Known cardiac disease
- Cardiovascular medication
- Medication that might influence cardiovascular health
- Smoking
The study team makes the final eligibility decision.
Where it's taking place
- Lund, Sweden
Compensation & support
A stipend or compensation may be offered.
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Lund, Sweden. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.