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New treatment option for Psoriasis
Official title Use of Total-Body PET to Quantify Systemic and Cutaneous Inflammation in Psoriasis Patients Before and After Intervention With a Nutritionally Balanced Diet
ClinicalTrials.gov ID: NCT06574178
What this study is testing
- What it's testing
- Psoriasis is a chronic inflammatory disease that affects the skin and joints in 2-3 % of people in the United States. This inflammation of the skin, joints, and blood vessels in patients with psoriasis has been measured by older PET Scan technology but with limitations.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adults (\>18 year)
- Both sexes
- Must have a history of psoriasis of at least 3% body surface area affected by skin psoriasis (in a body area that the subject will allow the PI to...
- Patients will have a BMI of \>/=25 which is consistent with being overweight - Willing and able to fast for at least 6 hours before and for the...
- No strenuous exercise for 24 hours prior to being scanned
You likely can't join if
- Those taking anti-diabetic oral or injected medications
- Those already ingesting a caloric- or component-restricted diet
- Vegan, vegetarian or food allergy or intolerance to the ingredients of the diet
- \>5% change in body weight in the last 2 months
- Those taking systemic medications for the purpose of treating psoriasis or psoriatic arthritis for at least 3 months prior to first PET scan or...
- Self-reported history of dysphoria or anxiety in closed spaces (claustrophobia)
See the full eligibility criteria
- Adults (\>18 year)
- Both sexes
- Must have a history of psoriasis of at least 3% body surface area affected by skin psoriasis (in a body area that the subject will allow the PI to perform several skin biopsies as noted below (optional)) and may carry a...
- Patients will have a BMI of \>/=25 which is consistent with being overweight - Willing and able to fast for at least 6 hours before and for the duration of the scan visit
- No strenuous exercise for 24 hours prior to being scanned
- Recruited patients must habitually consume a WD-type diet that will be evaluated by using DHQ III food frequency questionnaire along with three-day food record14. Subsequently, the Healthy Eating Index will be...
- Those taking anti-diabetic oral or injected medications
- Those already ingesting a caloric- or component-restricted diet
- Vegan, vegetarian or food allergy or intolerance to the ingredients of the diet
- \>5% change in body weight in the last 2 months
- Those taking systemic medications for the purpose of treating psoriasis or psoriatic arthritis for at least 3 months prior to first PET scan or during the duration of the trial
- Self-reported history of dysphoria or anxiety in closed spaces (claustrophobia)
- Uncontrolled diabetes or blood glucose level greater than 180 mg/dl at the time of radiotracer injection
- Body weight \>240 kg due to limitations of the scanner bed
- Known inflammatory or other infectious disease that can confound assessment
- Pregnant or breast-feeding (urine pregnancy test will be administered prior to start of each PET/CT session for all participants who are able to get pregnant between 18 to 60 years old, unless documented hysterectomy or...
- Inability to lie motionless on the scanner bed with the arms by the side for up to 60 minutes
- Currently participating in another conflicting research study. Concurrent or prior enrollment in a separate research study involving a PET scan performed within the last 12 months for research purposes only.
- Unwilling to sign informed consent
- Inability to understand the risks and benefits of the study
- Prisoners
The study team makes the final eligibility decision.
Where it's taking place
- Sacramento, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Sacramento, California, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.