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New treatment option for Heart Failure
Official title The Gut Microbiome in Chronic Heart Failure
ClinicalTrials.gov ID: NCT06573892
What this study is testing
- What it's testing
- there are numerous studies, most of which are predominantly associative in nature, investigating the association between the gut microbiota and various pathologies. However, to establish a causal relationship between microbiome composition and chronic heart failure (HF), clinical studies are needed, particularly using probiotics that can modify the composition and function of the gut microbiota.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age over 18 years
- Residing in the city of Astana and surrounding regions (Akmola region)
- Diagnosis of heart failure according to internationally recognized guidelines and classified as Class I-IV by NYHA (New York Heart Association) or...
- Clinically stable condition and optimized medication therapy for heart failure for at least 4 weeks in accordance with current recommendations
- Willingness to participate in the study
You likely can't join if
- Age under 18 years
- Refusal to undergo diagnostic procedures specified in the study protocol
- Terminal stage of heart failure (Stage D according to ACC/AHA classification)
- Coronary or peripheral revascularization procedures, valvular procedures, or any major surgical procedure within 3 months prior to study enrollment
- Use of antibiotics, cytostatic therapy, or pro- or prebiotics within 1 month prior to the baseline visit
- Presence of oncological and autoimmune diseases (connective tissue diseases, gastrointestinal disorders, skin disorders, etc.)
See the full eligibility criteria
- Age over 18 years
- Residing in the city of Astana and surrounding regions (Akmola region)
- Diagnosis of heart failure according to internationally recognized guidelines and classified as Class I-IV by NYHA (New York Heart Association) or Stage A-C according to ACC/AHA (American College of Cardiology/American...
- Clinically stable condition and optimized medication therapy for heart failure for at least 4 weeks in accordance with current recommendations
- Willingness to participate in the study
- Age under 18 years
- Refusal to undergo diagnostic procedures specified in the study protocol
- Terminal stage of heart failure (Stage D according to ACC/AHA classification)
- Coronary or peripheral revascularization procedures, valvular procedures, or any major surgical procedure within 3 months prior to study enrollment
- Use of antibiotics, cytostatic therapy, or pro- or prebiotics within 1 month prior to the baseline visit
- Presence of oncological and autoimmune diseases (connective tissue diseases, gastrointestinal disorders, skin disorders, etc.)
- Acute illness or active infection
- Individual intolerance to the administered nutrients (probiotics)
- Presence of other anatomical or comorbid conditions, or other medical, social, or psychological conditions that, in the investigator's opinion, may limit the subject's ability to participate in the clinical study...
The study team makes the final eligibility decision.
Where it's taking place
- Astana, Kazakhstan
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Astana, Kazakhstan. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.