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New treatment option for Vestibular Schwannoma
Official title USPIO Enhanced MR Imaging in CNS Tumours (UMIC)
ClinicalTrials.gov ID: NCT06572475
What this study is testing
- What it's testing
- The immune response or inflammation is known to be a key driver of progression and growth in many solid tumours. Inflammatory cells called macrophages are present in high numbers in many brain tumours and these tumour associated macrophages or TAM are thought to have prognosis and treatment implications in these tumours.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 16 to 100
You may be able to join if
- Be at least 16 years old
- Have a CNS tumour suspected to be one of the defined histological types (vestibular scwhannoma or low grade glioma)
- Be able to lie still for up to 1 hour comfortably
- Opinion of the treating clinician is that the patient will be able to successfully complete the research imaging protocol.
You likely can't join if
- Life expectancy less than 1 year
- Previous CNS radiotherapy/ stereotactic radiosurgery (SRS)
- Females who are pregnant/ breastfeeding
- Patients with an eGFR \< 30ml/min
- Patients with known and documented history of iron overload/haemosiderosis/ haemochromatosis
- Patients with immune or inflammatory conditions e.g. systemic lupus erythematous, rheumatoid arthritis
See the full eligibility criteria
- Be at least 16 years old
- Have a CNS tumour suspected to be one of the defined histological types (vestibular scwhannoma or low grade glioma)
- Be able to lie still for up to 1 hour comfortably
- Opinion of the treating clinician is that the patient will be able to successfully complete the research imaging protocol.
- Life expectancy less than 1 year
- Previous CNS radiotherapy/ stereotactic radiosurgery (SRS)
- Females who are pregnant/ breastfeeding
- Patients with an eGFR \< 30ml/min
- Patients with known and documented history of iron overload/haemosiderosis/ haemochromatosis
- Patients with immune or inflammatory conditions e.g. systemic lupus erythematous, rheumatoid arthritis
- Patients with absolute (e.g. pacemaker) and relative (anxiety or claustrophobia) contraindications to MR scanning
- Patients with a history of allergic reaction to iron or dextran
- Patients with a history of allergic reaction to gadolinium contrast agents, asthma or renal problems
- Patients who are unable to adequately understand verbal explanations or written information given in English.
The study team makes the final eligibility decision.
Where it's taking place
- Salford, Greater Manchester, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 16 years to 100 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Salford, Greater Manchester, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.