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Tests treatment safety and results for Septic Shock
Official title Fluid Intolerance Signals as Safety Limits to Prevent Fluid-induced Harm During Septic Shock Resuscitation
ClinicalTrials.gov ID: NCT06568744
What this study is testing
- What it's testing
- The goal of this multicentric randomized controlled trial is to compare, in septic shock patients who require further fluid resuscitation, two strategies of administering fluids. The intervention group will integrate fluid intolerance signals to the decision making process, while the control group will follow standard of care, for a 6 hour study protocol.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 100
You may be able to join if
- Diagnosed or suspected septic shock
- \< 24 hours since diagnosis
- Hypoperfusion signal (altered arterial lactate or CRT) that requires further resuscitation
- Mechanical ventilation
- Positive fluid responsiveness status
You likely can't join if
- Pregnancy
- Do-not-resuscitate status
- Acute coronary syndrome
- Active bleeding
- Severe concomitant acute respiratory distress syndrome (ARDS) (PaO2:FiO2 ratio \< 100)
- Anticipated surgery, prone positioning, or renal replacement therapy in the next 6 hours
See the full eligibility criteria
- Diagnosed or suspected septic shock
- \< 24 hours since diagnosis
- Hypoperfusion signal (altered arterial lactate or CRT) that requires further resuscitation
- Mechanical ventilation
- Positive fluid responsiveness status
- Pregnancy
- Do-not-resuscitate status
- Acute coronary syndrome
- Active bleeding
- Severe concomitant acute respiratory distress syndrome (ARDS) (PaO2:FiO2 ratio \< 100)
- Anticipated surgery, prone positioning, or renal replacement therapy in the next 6 hours
- Refractory shock according to attending physician
- BMI \> 40.
- Inadequate echocardiographic window
The study team makes the final eligibility decision.
Where it's taking place
- Quillota, Chile
- Santiago, Chile
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 100 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Quillota, Chile; Santiago, Chile. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.