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New treatment option for Biliary Tract Cancers
Official title Targeting Driver Oncogenes With a Peptide Vaccine Plus Durvalumab and Tremelimumab for Patients With Biliary Tract Cancers (BTC)
ClinicalTrials.gov ID: NCT06564623
What this study is testing
What is mBTC vax [0.3 - 2.4 mg peptide + 0.5 mg Poly-ICLC (Hiltonol)]?
mBTC vax [0.3 - 2.4 mg peptide + 0.5 mg Poly-ICLC (Hiltonol)] is an investigational medicine, being studied as a potential treatment for biliary tract cancers.
Also referred to as Peptide + Poly-ICLC (Hiltonol).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to evaluate the safety and the immune response of personalized mutant peptide vaccine with poly-ICLC adjuvant (mBTCvax) in combination with durvalumab and tremelimumab following front-line treatment in patients with advanced stage BTC.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥18 years
- Must have a histologically- or cytologically, proven biliary tract cancer (BTC) previously treated with gemcitabine/cisplatin/anti-PD(L)1 therapy.
- Must have evidence of radiological disease, must accept to have a tumor biopsy of an accessible lesion at baseline and on treatment.
- Must have sufficient archival tumor tissue for next-generation sequencing (NGS) and immune-phenotyping.
- Have a BTC containing at least one of the oncogenic mutation/alterations targeted by the vaccine.
You likely can't join if
- Participation in another clinical study with an investigational product during the last 2 weeks.
- Patient is expected to require any other form of systemic or localized antineoplastic therapy while on study.
- Any of the following procedures or medications within 2 weeks prior to initiation of study treatment:
- Systemic or topical steroids at immunosuppressive doses (\> 10 mg/day of prednisone or equivalent). The following are exceptions to this criterion:
- Intranasal, inhaled, topical steroids, or local steroid injections (e.g., intra articular injection)
- Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or its equivalent
See the full eligibility criteria
Who can join
- Age ≥18 years
- Must have a histologically- or cytologically, proven biliary tract cancer (BTC) previously treated with gemcitabine/cisplatin/anti-PD(L)1 therapy.
- Must have evidence of radiological disease, must accept to have a tumor biopsy of an accessible lesion at baseline and on treatment.
- Must have sufficient archival tumor tissue for next-generation sequencing (NGS) and immune-phenotyping.
- Have a BTC containing at least one of the oncogenic mutation/alterations targeted by the vaccine.
- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1.
- Must have body weight of \>30 kg.
- Patients must have adequate organ and marrow function defined by study-specified laboratory tests.
- Patients with chronic or acute hepatitis B virus (HBV) or hepatitis C virus (HCV) infection must have disease controlled prior to enrollment.
- Women of childbearing potential (WOCBP) must have a negative urine or serum pregnancy test.
- For both Women and Men, must use acceptable form of birth control while on study.
- Must have a life expectancy of at least 12 weeks.
- Ability to understand and willingness to sign a written informed consent document.
What rules you out
- Participation in another clinical study with an investigational product during the last 2 weeks.
- Patient is expected to require any other form of systemic or localized antineoplastic therapy while on study.
- Any of the following procedures or medications within 2 weeks prior to initiation of study treatment:
- Systemic or topical steroids at immunosuppressive doses (\> 10 mg/day of prednisone or equivalent). The following are exceptions to this criterion:
- Intranasal, inhaled, topical steroids, or local steroid injections (e.g., intra articular injection)
- Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or its equivalent
- Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication)
- Palliative or adjuvant radiation or gamma knife radiosurgery.
- Chemotherapy or checkpoint inhibitor targeting anti-Pd1/PD-L1.
- Within 4 weeks prior to initiation of study treatment:
- Any investigational cytotoxic drug.
- Any investigational device.
- Non-oncology vaccines containing live virus.
- Allergen hyposensitization therapy.
- Growth factors, e.g. granulocyte-colony stimulating factor (G-CSF), granulocyte macrophage-colony stimulating factor (GM-CSF), erythropoietin.
- Major surgery.
- Any unresolved toxicity NCI CTCAE Grade ≥2 from previous anticancer therapy with the exception of alopecia, vitiligo, and the laboratory values defined in the inclusion criteria.
- Patients with Grade ≥2 neuropathy will be evaluated on a case-by-case basis after consultation with the Study Physician.
- All AEs while receiving prior immunotherapy must have completely resolved or resolved to baseline prior to screening for this study.
- Must not have experienced a ≥Grade 3 immune related AE or an immune related neurologic or ocular AE of any grade while receiving prior immunotherapy.
- Patients with a history of prior treatment with anti-PD-1 and anti-PD-L1.
- History of severe hypersensitivity reaction to any monoclonal antibodies or related compounds or to any of its components.
- History of leptomeningeal carcinomatosis.
- Patient has a known history or evidence of brain metastases.
- Has an active known or suspected autoimmune disease or which has required systemic therapy in the last 5 years.
- Known history of interstitial lung disease or of (non-infectious) pneumonitis that required steroids or current pneumonitis.
- Has a pulse oximetry \< 92% on room air.
- Requires the use of home oxygen.
- Has a known history of Human Immunodeficiency Virus (HIV)/AIDS
- Has active co-infection with HBV (hepatitis B virus) and HCV (hepatitis C virus) or coinfected with HBV and hepatitis delta virus (HDV)
- Uncontrolled intercurrent illness including, but not limited to, uncontrolled infection, symptomatic congestive heart failure, unstable angina, cardiac arrhythmia, metastatic cancer, or psychiatric illness/social...
- Patients who have been diagnosed with another cancer or myeloproliferative disorder in the past 5 years requiring systemic therapy or expected to require active therapy within the clinical study period.
- Has a diagnosis of immunodeficiency.
- Presence of any tissue or organ allograft, regardless of need for immunosuppression, including corneal allograft. Patients with a history of allogeneic hematopoietic stem cell transplant will be excluded.
- Any other sound medical, psychiatric, and/or social reason as determined by the Investigator.
- Patient is at the time of signing informed consent a regular user (including "recreational use") of any illicit drugs or had a recent history (within the last year) of substance abuse (including alcohol).
- Patient is unwilling or unable to follow the study schedule for any reason.
- Pregnant or breastfeeding.
- WOCBP and men with female partners (WOCBP) who are not willing to use contraception.
- Evidence of clinical ascites requiring paracentesis in the last 4 weeks.
- History of malignant bowel obstruction.
The study team makes the final eligibility decision.
Where it's taking place
- Baltimore, Maryland, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Baltimore, Maryland, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.