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New treatment option for Opioid Consumption
Official title Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy
ClinicalTrials.gov ID: NCT06563349
What this study is testing
What is Intravenous magnesium sulfate?
Intravenous magnesium sulfate is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for opioid consumption.
Also referred to as IVM (intravenous magnesium).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Magnesium sulfate is one of the most commonly used co-analgetics. Its antinociceptive effect is related to antagonizing NMDA (N-methyl-D-aspartate) receptors of the nervous system, has an anti-inflammatory effect by reducing the concentration of IL-6 (interleukin 6) and tumor necrosis factor alpha.
- Phase 4: studies an already-approved treatment
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 18
You may be able to join if
- ASA (American Society of Anesthesiologists) physical status class 1E, 2E, 3E (E - emergency)
- Patients undergoing laparoscopic appendectomy
You likely can't join if
- Allergy to the magnesium sulfate or the excipient
- Hypermagnesemia
- Renal failure (GFR \<30 ml/min)
- Myasthenia gravis
- Preoperative atrioventricular block
- Hypotension
See the full eligibility criteria
- ASA (American Society of Anesthesiologists) physical status class 1E, 2E, 3E (E - emergency)
- Patients undergoing laparoscopic appendectomy
- Allergy to the magnesium sulfate or the excipient
- Hypermagnesemia
- Renal failure (GFR \<30 ml/min)
- Myasthenia gravis
- Preoperative atrioventricular block
- Hypotension
- The use of digitalis glycosides
- The use of oral anticoagulants
- ASA physical status class 4E or higher
- Chronic treatment with analgesics
- Legal guardians or patient refusal
The study team makes the final eligibility decision.
Where it's taking place
- Warsaw, Poland
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 months to 18 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Warsaw, Poland. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.