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New treatment option for Coma
Official title Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation-2 (TELSTAR-2)
ClinicalTrials.gov ID: NCT06549426
What this study is testing
What is anti-seizure medication + sedative agent(s)?
anti-seizure medication + sedative agent(s) is an investigational medicine, being studied as a potential treatment for coma.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this comparative effectiveness trial is to study electrographic status epilepticus (ESE) treatment in comatose patients after cardiac arrest. The main questions the trial aims to answer are: Does ESE treatment improve outcome?
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Coma (Glasgow Coma Scale score ≤ 8) after out of hospital cardiac arrest and resuscitation
- Age ≥ 18 years
- Continuous EEG with at least eight electrodes started \< 24h after return of spontaneous circulation (ROSC)
- ESE or possible ESE according to the Salzburg and ACNS criteria
- Possibility to start treatment within three hours after detection of ESE
You likely can't join if
- Known history of another medical condition with limited life expectancy (\< six months)
- Any progressive brain illness, such as a brain tumor or neurodegenerative disease
- Pre-admission Glasgow Outcome Scale score of 3 or lower
- Reason other than the neurological condition to withdraw treatment
- EEG background activity prior to the emergence of ESE indicative of extensive irreversible anoxic brain injury
- Follow-up impossible due to logistic reasons, for example not living in the Netherlands or Belgium
The study team makes the final eligibility decision.
Where it's taking place
- Brussels, Belgium
- Charleroi, Belgium
- Liège, Belgium
- Louvière, Belgium
- Ottignies, Belgium
- Amsterdam, Netherlands
- Arnhem, Netherlands
- Breda, Netherlands
- Eindhoven, Netherlands
- Enschede, Netherlands
- Groningen, Netherlands
- Leiden, Netherlands
- Nieuwegein, Netherlands
- Nijmegen, Netherlands
- Rotterdam, Netherlands
- The Hague, Netherlands
- Venlo, Netherlands
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Brussels, Belgium; Charleroi, Belgium; Liège, Belgium; Louvière, Belgium; Ottignies, Belgium; Amsterdam, Netherlands and 11 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.