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New treatment option for Critical Illness
Official title Use of Vasopressin in Patients at High Risk of Acute Kidney Injury Admitted to the ICU
ClinicalTrials.gov ID: NCT06547892
What this study is testing
What is Vasopressin?
Vasopressin is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for critical illness.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Renal dysfunction is a frequent complication in patients admitted to intensive care units (ICUs), associated with high morbidity and mortality. Current therapeutic options to prevent this condition are limited and lack robust scientific evidence.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adult patients (≥18 years old);
- Admitted to intensive care units;
- Predicted risk of acute kidney injury calculated based on clinical and laboratory data at ICU admission and is considered eligible if the value in...
You likely can't join if
- Time since admission to the ICU greater than 24 hours;
- Use of vasopressors at the time of inclusion;
- MAP \>90 mmHg;
- Hyponatremia (\<130 mmol/L);
- Severe TBI with Glasgow Coma Scale \< 8;
- Elective surgeries;
See the full eligibility criteria
- Adult patients (≥18 years old);
- Admitted to intensive care units;
- Predicted risk of acute kidney injury calculated based on clinical and laboratory data at ICU admission and is considered eligible if the value in the calculator is equal or greater than 5 points;
- Time since admission to the ICU greater than 24 hours;
- Use of vasopressors at the time of inclusion;
- MAP \>90 mmHg;
- Hyponatremia (\<130 mmol/L);
- Severe TBI with Glasgow Coma Scale \< 8;
- Elective surgeries;
- Dialysis chronic kidney disease or acute kidney injury who received renal replacement therapy upon admission or are expected to receive renal replacement therapy within the next 24 hours;
- Suspected or confirmed acute mesenteric ischemia;
- Prospect of death in less than 24 hours;
- Medical team not committed to full investment at the time of inclusion;
- Prior inclusion in the study;
- Pregnancy.
The study team makes the final eligibility decision.
Where it's taking place
- São Paulo, São Paulo, Brazil
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include São Paulo, São Paulo, Brazil. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.