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New treatment option for Pregnancy Complications
Official title Study on the Effect of Combined Estrogen and Progestogen Therapy on Endometrial Repair After Induced Abortion
ClinicalTrials.gov ID: NCT06546397
What this study is testing
What is 17β-estradiol/dydrogesterone tablets?
17β-estradiol/dydrogesterone tablets is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for pregnancy complications.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Induced abortion is a common method to terminate pregnancy, but during the operation, it is necessary to dilate the cervix and aspirate the uterine cavity. Repeated induced abortions may increase the risk of uterine damage, leading to cervical stenosis or intrauterine adhesions, thinning of the endometrium, which may affect the implantation of fertilized eggs and the development of embryos, and ultimately may lead to infertility or miscarriage.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 40, women only
You may be able to join if
- Age between 18 years old (inclusive) and 40 years old (inclusive)
- Body Mass Index (BMI) ranging from 18.5Kg/㎡ to 23.9Kg/㎡
- Experienced at least 2 abortions or had a missed abortion
- Confirmed gestational age of no more than 10 weeks, and the ultrasonic examination within three days prior to the surgery shows a gestational sac...
- Normal preoperative examination results as per the "Clinical Diagnosis and Treatment Guidelines and Technical Operation Standards: Family Planning...
You likely can't join if
- Individuals with contraindications to estrogen and progesterone therapy
- History of uterine adhesions confirmed by hysteroscopy, or a history of uterine cavity surgery or uterine malformation correction
- people who require placement of an intrauterine device or administration of oral contraceptives or subcutaneous implants after the procedure
- Individuals with mental status or cognitive function abnormalities who are unable to cooperate with the treatment process
- people who, in the opinion of the investigator, have potential risks or any other factors that may interfere with the study.
See the full eligibility criteria
- Age between 18 years old (inclusive) and 40 years old (inclusive)
- Body Mass Index (BMI) ranging from 18.5Kg/㎡ to 23.9Kg/㎡
- Experienced at least 2 abortions or had a missed abortion
- Confirmed gestational age of no more than 10 weeks, and the ultrasonic examination within three days prior to the surgery shows a gestational sac (average of three diameters) of at least 1.0cm, with an embryo length of...
- Normal preoperative examination results as per the "Clinical Diagnosis and Treatment Guidelines and Technical Operation Standards: Family Planning Volume (2017 Revision)"
- Capable of regular follow-ups and willing to sign the informed consent form.
- Individuals with contraindications to estrogen and progesterone therapy
- History of uterine adhesions confirmed by hysteroscopy, or a history of uterine cavity surgery or uterine malformation correction
- people who require placement of an intrauterine device or administration of oral contraceptives or subcutaneous implants after the procedure
- Individuals with mental status or cognitive function abnormalities who are unable to cooperate with the treatment process
- people who, in the opinion of the investigator, have potential risks or any other factors that may interfere with the study.
The study team makes the final eligibility decision.
Where it's taking place
- Hangzhou, Zhejiang, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 18 years to 40 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Hangzhou, Zhejiang, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.