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New treatment option for Cryopyrin Associated Periodic Syndrome
Official title Circadian Rhythm Deregulation in Patients With CAPS
ClinicalTrials.gov ID: NCT06544018
What this study is testing
What is Genetic analysis of NLRP3?
Genetic analysis of NLRP3 is an investigational medicine, given as an once-daily, being studied as a potential treatment for cryopyrin associated periodic syndrome.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Circadian rhythms are characterized by the physiology's adaptation to the alternation of day and night, enabling to adapt to the environment. These rhythms are generated by a molecular clock within each cell.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 6 and older. Healthy volunteers may be eligible.
You may be able to join if
- --- Patient with CAPS group :
- Patients aged 6 and over
- Participant with CAPS confirmed by NLRP3 genetic analysis
- Weight greater than or equal to 25 Kg
- Parents/guardians who have been informed of the study and have signed a consent form.
You likely can't join if
- Patient with CAPS group :
- Patients with chronic sleep disorders (narcolepsy, hypersomnia) requiring medication (sleeping pills, melatonin).
- Patients with sleep apnea syndrome
- Patients working regular night shifts or alternating day and night shifts
- Pregnant or breast-feeding women
- Parents with an infant under 6 months of age
See the full eligibility criteria
- --- Patient with CAPS group :
- Patients aged 6 and over
- Participant with CAPS confirmed by NLRP3 genetic analysis
- Weight greater than or equal to 25 Kg
- Parents/guardians who have been informed of the study and have signed a consent form.
- Patient affiliated to a social security scheme Control group (healthy participant):
- Participant aged 6 and over
- Weight greater than or equal to 25 Kg
- Participant living in the same household as a subject with CAPS genetically confirmed by NLRP3 analysis and included in the protocol
- Participant with no CAPS (a priori) who consents to NLRP3 genetic analysis
- Parents/guardians who have been informed of the study and have signed a consent form.
- Participant who has been informed of the study and has agreed to take part
- Participant affiliated to a social security scheme
- Patient with CAPS group :
- Patients with chronic sleep disorders (narcolepsy, hypersomnia) requiring medication (sleeping pills, melatonin).
- Patients with sleep apnea syndrome
- Patients working regular night shifts or alternating day and night shifts
- Pregnant or breast-feeding women
- Parents with an infant under 6 months of age
- Patient participating in another treatment drug study
- Deprivation of civil rights (curators, guardianship, safeguard of justice) Control group (healthy participant):
- Participants with a chronic illness (ALD beneficiaries)
- Participants with chronic sleep disorders (narcolepsy, hypersomnia) requiring medication (sleeping pills, melatonin)
- Participants working regular night shifts or alternating day and night shifts
- Pregnant or breast-feeding women
- Parents with an infant under 6 months of age
- Participant participating in another treatment drug study
- Deprivation of civil rights (curators, guardianship, safeguard of justice)
The study team makes the final eligibility decision.
Where it's taking place
- Bron, France
- Lille, France
- Lyon, France
- Paris, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 6 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bron, France; Lille, France; Lyon, France; Paris, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.