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New treatment option for Obesity
Official title Comorbid Obesity and Depression With an Anti-inflammatory Medication
ClinicalTrials.gov ID: NCT06537921
What this study is testing
What is Minocycline 200mg?
Minocycline 200mg is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for obesity.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Research suggests that only a subset of individuals with major depressive disorder (MDD) may benefit from anti-inflammatory treatments: those who have C-reactive protein (CRP) ≥3 mg/L, a commonly used threshold for "low-grade" inflammation. The emerging link between metabolic and immune abnormalities in MDD suggests that individuals with comorbid obesity and MDD are a subset of people who could particularly benefit from anti-inflammatory treatment.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Sufficient communication skills to understand the intervention and complete the assessments.
- Able to give informed consent.
- Treatment resistant depressed (i.e., non-responders to current antidepressant treatment, for at least 6-weeks AND at least one other previous...
- Tolerant to the current antidepressant.
- Able to undergo 2 MRI scans.
You likely can't join if
- Active suicidal ideation.
- Current primary diagnosis of psychotic disorder, bipolar disorder, obsessive-compulsive disorder, or post-traumatic stress disorder.
- Have an acute infection or an autoimmune disorder, because of both the rare but described association between minocycline and systemic lupus...
- Alcohol misuse disorder or drug addiction.
- Neurological disorders (Parkinson's, Alzheimer's).
- Current serious cardiovascular problems.
See the full eligibility criteria
- Sufficient communication skills to understand the intervention and complete the assessments.
- Able to give informed consent.
- Treatment resistant depressed (i.e., non-responders to current antidepressant treatment, for at least 6-weeks AND at least one other previous antidepressant).
- Tolerant to the current antidepressant.
- Able to undergo 2 MRI scans.
- Accepting augmentation with minocycline.
- CRP \>3mg/L at screening.
- No plans to change current therapy for the duration of participation.
- Active suicidal ideation.
- Current primary diagnosis of psychotic disorder, bipolar disorder, obsessive-compulsive disorder, or post-traumatic stress disorder.
- Have an acute infection or an autoimmune disorder, because of both the rare but described association between minocycline and systemic lupus erythematosus, and the potential confounder effects of these conditions on...
- Alcohol misuse disorder or drug addiction.
- Neurological disorders (Parkinson's, Alzheimer's).
- Current serious cardiovascular problems.
- Have acne or psoriasis.
- Currently taking any antibiotic, immunosuppressive medication, or warfarin.
- Taken any tetracycline within the last month.
- Currently taking Lithium or retinoids (Acitretin, Alitretinoin, Isotretinoin).
- Refuse that we contact their GP to inform them about their participation.
- [OPTIONAL - if not met, cannot undergo the MRI] Has any metal implants in their body such as pacemakers, dental fillings, IUD device (if applicable), or had any accidents where metal fragments might have entered the...
- Pregnant or breastfeeding
- Have a positive pregnancy test before starting the study/are unwilling to take a pregnancy test and are unwilling to agree to use an acceptable form of contraceptive throughout the study period (e.g., condoms...
- Are currently participating in another Clinical Trial of Investigational Medicinal Product (CTIMP).
The study team makes the final eligibility decision.
Where it's taking place
- London, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include London, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.