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New treatment option for Arthralgia
Official title The MUSE Study for Menopausal Arthralgia
ClinicalTrials.gov ID: NCT06530459
What this study is testing
What is Menopausal hormone therapy?
Menopausal hormone therapy is an investigational medicine, given as an once-weekly pill taken by mouth, being studied as a potential treatment for arthralgia.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The investigators plan to conduct a pilot 4-arm, randomized study comprising the following interventions: muscle strengthening exercises (MSE) alone, estrogen therapy (ET) alone, and a combination of MSE and ET, compared to usual care in women with menopausal arthralgia. The aim of this pilot study is to assess the feasibility, patient acceptability, and patient perspectives and logistics of delivering interventions, and practicability of outcome assessment tools in this 4-arm study over a 12-week period.
- Phase 3: a large, late-stage study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 30 to 59, women only. Healthy volunteers may be eligible.
You may be able to join if
- Patients with muscle stiffness and joint discomfort in various sites, including hands, knees, back, hips, and/or shoulders. Patients with pain in...
- Arthralgia symptoms with onset, or has become worse, over the perimenopausal or early postmenopausal period (within 5 years of the menopause).
- Women should be at the menopause transition, less than or equal to 59 years old at the time of enrollment, or within 5 years of menopause whichever...
- Arthralgia for at least 3 months (pain lasting beyond normal injury healing period)
- Community-dwelling and able to ambulate independently.
You likely can't join if
- History of thrombo-embolic diseases, strokes, ischemic heart disease, dementia or psychiatric disorders, active liver disease or renal impairment...
- Pregnancy
- Non-adherence to national guidelines for breast cancer screening
- High risk for breast cancer
- Any joint surgery within the last 6 months
- Severe obesity: BMI\>35
See the full eligibility criteria
- Patients with muscle stiffness and joint discomfort in various sites, including hands, knees, back, hips, and/or shoulders. Patients with pain in only one isolated joint would not be accepted.
- Arthralgia symptoms with onset, or has become worse, over the perimenopausal or early postmenopausal period (within 5 years of the menopause).
- Women should be at the menopause transition, less than or equal to 59 years old at the time of enrollment, or within 5 years of menopause whichever is earlier. .
- Arthralgia for at least 3 months (pain lasting beyond normal injury healing period)
- Community-dwelling and able to ambulate independently.
- History of thrombo-embolic diseases, strokes, ischemic heart disease, dementia or psychiatric disorders, active liver disease or renal impairment, severe hyperlipidemia, gout, thyroid disease, systemic lupus...
- Pregnancy
- Non-adherence to national guidelines for breast cancer screening
- High risk for breast cancer
- Any joint surgery within the last 6 months
- Severe obesity: BMI\>35
- Migraine with aura
- Poorly controlled diabetes
- Use of any form of female hormone supplementation within the past 12 weeks.
- High venous thromboembolism risk
- Current cholecystitis, fibroids, or undiagnosed abnormal uterine bleeding.
- Current smoker.
- History of endometrial, ovarian, peritoneal, cervical, breast or endocrine-dependent cancers.
- Receiving treatment for any form of cancer.
- History of fragility bone fractures within the 2 years.
- Any other cognitive, musculoskeletal, neurological, and cardiorespiratory condition affecting one's ability to participate in the study.
The study team makes the final eligibility decision.
Where it's taking place
- Singapore, Singapore
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 30 years to 59 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Singapore, Singapore. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.