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New treatment option for ARDS
Official title Effect of Different Depths of Neuromuscular Blockade on Respiratory Mechanics in Patients With Moderate-severe Acute Respiratory Distress Syndrome
ClinicalTrials.gov ID: NCT06514209
What this study is testing
What is cisatracurium?
cisatracurium is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for ards.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Acute respiratory distress syndrome (ARDS) is characterized by acute diffuse alveolar injury caused by a variety of pulmonary and extrapulmonary factors, leading to refractory hypoxemia. It has high incidence and mortality rates.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 85
You may be able to join if
- Patients with moderate to severe ARDS requiring the use of NMBAs, as assessed by clinicians (Berlin definition 2012: PaO2/FiO2 \< 150 mmHg, PEEP ≥ 5).
- Age: 18-85 years.
- Signed informed consent.
You likely can't join if
- History of allergy to NMBAs.
- Open chest or abdominal injuries.
- Patients with pulmonary masses, lung transplantation, or lung resection.
- Contraindications to esophageal catheter placement.
- Pregnant patients.
- Contraindications to TOF measurement (e.g., history of neuromuscular disease, presence of a cardiac pacemaker).
See the full eligibility criteria
- Patients with moderate to severe ARDS requiring the use of NMBAs, as assessed by clinicians (Berlin definition 2012: PaO2/FiO2 \< 150 mmHg, PEEP ≥ 5).
- Age: 18-85 years.
- Signed informed consent.
- History of allergy to NMBAs.
- Open chest or abdominal injuries.
- Patients with pulmonary masses, lung transplantation, or lung resection.
- Contraindications to esophageal catheter placement.
- Pregnant patients.
- Contraindications to TOF measurement (e.g., history of neuromuscular disease, presence of a cardiac pacemaker).
- Severe dysfunction of other organs with an expected short-term mortality (within 7 days) or palliative care.
- Previous inclusion in this study.
The study team makes the final eligibility decision.
Where it's taking place
- Nanjing, Jiangsu, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 days to 85 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Nanjing, Jiangsu, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.