BridgeMD
New treatment option for Obesity
Official title Exercise, Brain Activity, and Weight Maintenance
ClinicalTrials.gov ID: NCT06511310
What this study is testing
- What it's testing
- This study aims to explore how HIIT influences brain function, neural and molecular pathways related to weight control, setting the stage for future obesity intervention research.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70. Healthy volunteers may be eligible.
You may be able to join if
- Age 18-70 years
- Body mass index (BMI) \>19 kg/m2 and body weight\< 250kg
- Participants must have experienced a clinically significant weight regain, defined as over 10% of their maximum weight lost, within 1 to 5 years...
- In good general health with no conditions that could influence the outcome of the trial, and in the judgment of the investigator is a good candidate...
- Willing to adhere to the protocol requirements for the duration of the study
You likely can't join if
- Type 1 diabetes mellitus
- Peripheral neuropathy with insensate feet
- Recent blood donation within the last 2 months
- Use of beta-blockers
- Current pregnancy or breastfeeding
- Active Heart or lung disease
See the full eligibility criteria
- Age 18-70 years
- Body mass index (BMI) \>19 kg/m2 and body weight\< 250kg
- Participants must have experienced a clinically significant weight regain, defined as over 10% of their maximum weight lost, within 1 to 5 years following their bariatric surgery. They will be asked to self-report their...
- In good general health with no conditions that could influence the outcome of the trial, and in the judgment of the investigator is a good candidate for the study based on review of available medical history, physical...
- Willing to adhere to the protocol requirements for the duration of the study
- Type 1 diabetes mellitus
- Peripheral neuropathy with insensate feet
- Recent blood donation within the last 2 months
- Use of beta-blockers
- Current pregnancy or breastfeeding
- Active Heart or lung disease
- Severe hypertension (systolic \>160 mmHg or diastolic \>90 mmHg)
- Inability to exercise for any reason
- Any known contraindication to exercise testing based on current ACSM guidelines
- MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body
- Known presence of a structural brain lesion (e.g. tumor, cortical infarct)
- Presence of another neurologic disorder, which could impact findings (e.g. multiple sclerosis)
- History of cardiovascular disease, stroke, congestive heart failure
- Active hematological, renal, pulmonary or hepatic disorders
- Active treatment for cancer
- A history of active alcohol or substance abuse
- Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the study protocol
- History of claustrophobia and inability to tolerate an MRI
- Body weight \>250kgr and largest body diameter of 70cm as there is a certain weight and diameter limit of the MRI scanner
- Unwilling or unable to return for study visits, undergo neuropsychological testing and MRI imaging
- Left-handedness
The study team makes the final eligibility decision.
Where it's taking place
- Boston, Massachusetts, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Boston, Massachusetts, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.