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Official title Vestibular and Cortical Contributions to Transitions in Freezing of Gait in Parkinson's Disease
ClinicalTrials.gov ID: NCT06506058
What this study is testing
- What it's testing
- Currently, there is a lack of comprehensive knowledge about the role of vestibulospinal drive and cortical activity during self-initiated movement transitions in older adults and people with PD (both with and without FOG). This set of experiments has two primary purposes: to (1) understand the pathological neurophysiology underlying freezing of gait (FOG) during movement transitions and FOG-inducing movements and (2) identify neurological biomarkers associated with FOG and FOG-inducing movements.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 21 to 80. Healthy volunteers may be eligible.
You may be able to join if
- Participants with Parkinson's disease (with and without Freezing of Gait)
- Diagnosis of idiopathic PD.
- Age 40-80 years.
- Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters. Healthy Older Adults (Control participants)
- Age 40-80 years (this group will be age- and sex-matched to the PD and FOG group).
You likely can't join if
- Exclusion Criteria (for all participants):
- Any musculoskeletal disorder that affects the ability to stand or walk.
- History of musculoskeletal disorders that significantly affect movement of lower limbs.
- Uncorrected visual impairment that may affect participation or performance in the study.
- History of visual and/or vestibular conditions that may affect participation or performance in the study.
- Meet criteria for dementia with Lewy bodies, Multiple Systems Atrophy, Alzheimer's disease, dementia diagnosis, or other neurodegenerative disorder...
See the full eligibility criteria
- Participants with Parkinson's disease (with and without Freezing of Gait)
- Diagnosis of idiopathic PD.
- Age 40-80 years.
- Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters. Healthy Older Adults (Control participants)
- Age 40-80 years (this group will be age- and sex-matched to the PD and FOG group).
- Able to ambulate independently without the use of an assistive device (cane or walker).
- Normal capacity to perform complex activities of daily living independently based on informant or physician report. Healthy Young Adults
- Age 21-44 years (this group will be sex-matched to the PD and FOG group)
- Able to ambulate independently without the use of an assistive device (cane or walker)
- Exclusion Criteria (for all participants):
- Any musculoskeletal disorder that affects the ability to stand or walk.
- History of musculoskeletal disorders that significantly affect movement of lower limbs.
- Uncorrected visual impairment that may affect participation or performance in the study.
- History of visual and/or vestibular conditions that may affect participation or performance in the study.
- Meet criteria for dementia with Lewy bodies, Multiple Systems Atrophy, Alzheimer's disease, dementia diagnosis, or other neurodegenerative disorder other than Parkinson's disease.
- History of seizures, epilepsy, stroke, multiple sclerosis, or traumatic brain injury or other significant neurological disorders that may affect participation or performance in the study.
- History of muscular conditions of the neck and back, including whiplash.
- History of surgery on blood vessels, brain, or heart.
- Unexplained, recurring headaches or concussion within the last six months.
- Moderate to severe hearing impairment.
- people who are pregnant
- Reduced capacity to consent. This will be assessed using a 2-stage process. Initially, participants will be tested using the University of California, San Diego, Brief Assessment of Capacity to Consent (UBACC). If the...
- History of motion sickness (as EVS can exacerbate motion sickness).
- Intense physical exercise or consumption of alcohol in the 24 hours prior to any experiment that will include EVS testing.
- Recent history of migraine headaches.
- Intracranial metallic or magnetic devices.
- Pacemaker or any implanted device.
- Implanted deep brain stimulator or other neurosurgeries to treat PD.
- Use of medications that can cause dizziness. Additional exclusion criteria for Control Participants:
- Presence of parkinsonism or cognitive impairment (including dementia or mild cognitive impairment).
- Active central nervous system, systemic, psychiatric conditions or use of psychoactive medication that would adversely affect cognitive, neuropsychiatric, motor, or autonomic functioning.
The study team makes the final eligibility decision.
Where it's taking place
- Minneapolis, Minnesota, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 21 years to 80 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Minneapolis, Minnesota, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.