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Compares treatment options for Treatment Resistant Schizophrenia
Official title Effect of Atenolol Versus Ivabradine on HRV in TRS Patients on Clozapine With Tachycardia: A Randomised Control Trial.
ClinicalTrials.gov ID: NCT06505668
What this study is testing
What is Atenolol 25 mg?
Atenolol 25 mg is an investigational medicine, being studied as a potential treatment for treatment resistant schizophrenia.
Also referred to as Arm A.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Clozapine is the only drug approved for Treatment Resistant Schizophrenia. However, it has been associated with many adverse drug reactions including agranulocytosis, myocarditis, sialorrhea, constipation, orthostasis, tachycardia.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 60. Healthy volunteers may be eligible.
You may be able to join if
- All patients coming for treatment at the Out-patient department and In-patient department of the Department of Psychiatry fulfilling the following...
- Patients diagnosed with TRS (TRRIP consensus) receiving clozapine.
- Aged between 18 to 60 years of either sex
- Having baseline heart rate of \>100/minute.
- Written informed consent from Legally Authorized representative.
You likely can't join if
- Patients with any one of the following are excluded from the study:
- Already receiving Atenolol or Ivabradine.
- Patients having any contraindication to using Atenolol or Ivabradine.
- Receiving any other medication other than Clozapine known to cause autonomic dysregulation.
- Active substance use.
- Serious medical or neurological comorbidity.
The study team makes the final eligibility decision.
Where it's taking place
- Bhubaneswar, Odisha, India
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 60 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bhubaneswar, Odisha, India. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.