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New treatment option for Hypotension
Official title The Effect of phoSPHocreatine on mEdical Emergency Team (Met) tREated Patients
ClinicalTrials.gov ID: NCT06503016
What this study is testing
What is Phosphocreatine?
Phosphocreatine is an investigational medicine, being studied as a potential treatment for hypotension.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Unexpected deaths and unplanned intensive care unit (ICU) admissions are common during hospital stay and are often preceded by warning abnormalities in patients' vital signs. These abnormalities trigger Medical Emergency Team (MET) activation and up to 15% of patients visited by the MET is admitted to the ICU with an overall hospital stay after the MET intervention of approximately 2 weeks.
- Phase 3: a large, late-stage study
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Admitted in hospital (but outside ICU)
- Age\>=18 years
- Written informed consent
- Serum creatinine \<=2 mg/dl
- Patient with impending or underlying cardiac failure or cardiac arrest, irrespectively of the primitive organ failure, and the Medical Emergency Team...
You likely can't join if
- Age \< 18 years;
- Ongoing cardiac massage;
- Current hospital admission from a care nursing facility;
- Planned discharge to a care nursing facility;
- Reasons for withdrawal of life-sustaining therapy;
- History of kidney transplantation;
See the full eligibility criteria
- Admitted in hospital (but outside ICU)
- Age\>=18 years
- Written informed consent
- Serum creatinine \<=2 mg/dl
- Patient with impending or underlying cardiac failure or cardiac arrest, irrespectively of the primitive organ failure, and the Medical Emergency Team (MET) is called upon at least one of the following:
- Threatened airways;
- Respiratory arrest;
- Respiratory rate \ 36 breaths per min;
- Pulse rate \ 140 beats per min;
- Systolic blood pressure \< 90 mm Hg;
- Sudden fall in level of consciousness;
- Fall in Glasgow coma scale of \> 2 points.
- Age \< 18 years;
- Ongoing cardiac massage;
- Current hospital admission from a care nursing facility;
- Planned discharge to a care nursing facility;
- Reasons for withdrawal of life-sustaining therapy;
- History of kidney transplantation;
- Solitary kidney (by any reason);
- Serum Creatinine \> 2 mg/dl;
- Immediate need for ICU admission;
- Known allergy to PCr;
- Pregnancy;
- Previous enrollment and randomization into this trial;
- Administration of PCr in the previous 30 day.
The study team makes the final eligibility decision.
Where it's taking place
- Milan, Italy
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Milan, Italy. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.