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Compares treatment options for Endothelial Function
Official title Comparing Approaches to Assess Nitric Oxide-dependent Cutaneous Vasodilation
ClinicalTrials.gov ID: NCT06499844
What this study is testing
What is Acetylcholine?
Acetylcholine is an investigational medicine, given as an once-daily, being studied as a potential treatment for endothelial function.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The increase in skin blood flow in response to rapid local heating of the skin (i.e., cutaneous vasodilation) is commonly used to assess nitric oxide (NO)-dependent dilation and overall microvascular function. Historically, rapid local heating to 42°C was considered the standard approach for these assessments.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 30. Healthy volunteers may be eligible.
You may be able to join if
- men and women
- 18-30 years of age
You likely can't join if
- Current or recent (within 8 wks) use of medication that could conceivably alter microvascular function [including (but not limited to) stimulants...
- Changes or alterations in medication status (starting a new, additional, or different medication or changing the dose of a current medication)
- Unstable or diagnosed chronic clinical disease, including cardiovascular, metabolic, renal, hepatic, autonomic, autoimmune, or dermatological disease...
- Body mass index \ 35 kg/m2
- Pregnancy (including a positive urine pregnancy test) or breast-feeding
- Known allergies to pharmacological agents or study drugs
See the full eligibility criteria
- men and women
- 18-30 years of age
- Current or recent (within 8 wks) use of medication that could conceivably alter microvascular function [including (but not limited to) stimulants, antihypertensives, HMG-CoA reductase inhibitors]
- Changes or alterations in medication status (starting a new, additional, or different medication or changing the dose of a current medication)
- Unstable or diagnosed chronic clinical disease, including cardiovascular, metabolic, renal, hepatic, autonomic, autoimmune, or dermatological disease (e.g., hypertension, heart disease, diabetes, hyperlipidemia...
- Body mass index \ 35 kg/m2
- Pregnancy (including a positive urine pregnancy test) or breast-feeding
- Known allergies to pharmacological agents or study drugs
- Non-English-speaking. Participants need to understand English to follow instructions and comply with procedures conducted during the screening and experimental visits.
The study team makes the final eligibility decision.
Where it's taking place
- Iowa City, Iowa, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 30 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Iowa City, Iowa, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.