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New treatment option for Peripheral T Cells Lymphoma (PTCL)
Official title Polyspecific Antibodies in Lymphoproliferative T-cell Disorders
ClinicalTrials.gov ID: NCT06495723
What this study is testing
What is LIS1?
LIS1 is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for peripheral t cells lymphoma (ptcl).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This is a 2-part study consisting of a Part 1, dose escalation and dose-finding component to establish the Maximal Tolerated Dose (MTD), or Recommended Part 2 Dose (RP2D) of LIS1 as a single agent; followed by a Part 2, to investigate anti-tumors efficacy of LIS1 in selected subtypes of Peripheral TCell Lymphoma (PTCL) and to further evaluate its safety and tolerability at RP2D.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Provide signed, written informed consent.
- Is male or female, age ≥18 years old (at the time consent is obtained)
- For Part 1: Has a histological diagnosis of the following relapsed or refractory PTCL based on WHO 2022 classification of lymphoid neoplasms
- Intestinal T-cell and NK cell lymphoid proliferations and lymphomas (without NK cell neoplasms)
- Hepatosplenic T-cell lymphoma
You likely can't join if
- Is diagnosed with a bulky disease (≥10 cm).
- Has known history or presence of central nervous system involvement by leukemia or lymphoma.
- Has Mature T-cell and NK-cell leukemias (WHO 2022 criteria)
- Has T-lymphoblastic leukemia/lymphoma (WHO 2022 criteria)
- Has tumor-like lesions with T-cell predominance (WHO 2022 criteria)
- Has Primary cutaneous T-cell lymphomas (WHO 2022 criteria)
See the full eligibility criteria
Who can join
- Provide signed, written informed consent.
- Is male or female, age ≥18 years old (at the time consent is obtained)
- For Part 1: Has a histological diagnosis of the following relapsed or refractory PTCL based on WHO 2022 classification of lymphoid neoplasms
- Intestinal T-cell and NK cell lymphoid proliferations and lymphomas (without NK cell neoplasms)
- Hepatosplenic T-cell lymphoma
- Anaplastic large cell lymphoma
- Nodal TFH cell lymphoma
- Other peripheral t-cell lymphomas For Part 2: The type of PTCL will be defined based on SC review after completion of Part 1 and will be documented in the protocol amendment
- Had previously received 1 or more appropriate systemic therapies, including an alkylating agent and/or anthracycline, for treatment of the current disease (radiation therapy alone would not be acceptable as previous...
- Experienced disease progression during or after completion of most recent therapy or refractory disease.
- Has a measurable lesion by imaging: the longest diameter should be ≥1.5 cm for nodal lesions and \>1 cm for extra-nodal lesions.
- Experienced a toxicity of prior therapy: Participants must have recovered to less than Grade 1 or to baseline from toxicity of prior chemotherapy or biologic therapy and must not have had major surgery, chemotherapy...
- Has either unstained tissues (block or unstained slides) or stained slides and pathology report available for central review. If stained slides or unstained tissue are not available or insufficient, a fresh tumor tissue...
- Is able to provide a bone marrow aspirate and/or a biopsy no older than 3 months at screening and agrees to undergo post-treatment bone marrow aspirate or biopsy when required to confirm response.
- Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
- Has life expectancy of \>3 months.
- Has an adequate hematological and organ function at screening, including:
- Hemoglobin ≥8.0 g/dL (prior transfusion is acceptable)
- Absolute neutrophil count (ANC) ≥1000 cells/mm3 (without growth factor support within 7 days of ANC measurement)
- Platelet count ≥50,000 cells/mm3 (without growth factor support or transfusion within 7 days of platelets measurement)
- Creatinine clearance ≥30 mL/min
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \<3 × the upper limit of normal (ULN)
- Serum total bilirubin \<2 × ULN OR \<3 × ULN (for participants with Gilbert's Syndrome)
- Participants must be able to understand and sign an informed consent form.
- All participants must use adequate contraception during participation in this study and for 6 months following completing therapy.
What rules you out
- Is diagnosed with a bulky disease (≥10 cm).
- Has known history or presence of central nervous system involvement by leukemia or lymphoma.
- Has Mature T-cell and NK-cell leukemias (WHO 2022 criteria)
- Has T-lymphoblastic leukemia/lymphoma (WHO 2022 criteria)
- Has tumor-like lesions with T-cell predominance (WHO 2022 criteria)
- Has Primary cutaneous T-cell lymphomas (WHO 2022 criteria)
- Has any other active cancers, or history of treatment for invasive cancer ≤3 years. Note: Participants with stage I cancer who have received definitive local treatment at least 3 years previously and are considered...
- Received any of the following treatments prior to the first dose of study medication:
- Systemic chemotherapy, targeted small molecule therapy, or radiation therapy within 4 weeks (or 5 half-lives, whichever is shorter) before Cycle 1 Day 1. Participants that received local radiation therapy are eligible.
- Therapeutic anti-cancer antibodies \<4 weeks
- Any investigational drug in the last 4 weeks prior
- Any major surgery or immunotherapy within 28 days
- Toxin immunoconjugates \<4 weeks
- Nitrosoureas \<6 weeks
- Allogeneic hematologic stem cell transplant within 3 months
- Adaptive cellular therapy such as autologous or donor natural killer cell or T lymphocyte infusions within 90 days
- Systemic corticosteroids (prednisone or equivalent \>10 mg daily) within 2 weeks prior to the start of therapy, or 12 weeks if given to treat graft versus host disease (GVHD), except for physiological replacement doses...
- Systemic treatment for GVHD (including but not limited to oral or parenteral corticosteroids, ibrutinib, and extracorporeal phototherapy) within the last 12 weeks
- Is experiencing a toxicity (or AE) from prior anti-cancer treatment that has not resolved to Grade ≤1 or baseline.
- Has a known infection with human immunodeficiency virus (HIV) or serologic status reflecting active hepatitis B or C infection as follows:
- Presence of hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb). Participants with presence of HBcAb, but absence of HBsAg, are eligible only if hepatitis B virus (HBV) DNA is undetectable by an...
- Presence of hepatitis C virus (HCV) antibody. Participants with presence of HCV antibody are eligible only if HCV RNA is undetectable.
- Has a known active tuberculosis infection.
- Has an active fungal, bacterial, and/or viral infection requiring systemic therapy.
- Had a vaccination with a live vaccine within 35 days prior to the first dose of LIS1.
- If woman, is pregnant or nursing a child.
- Has an active autoimmune disease or history of autoimmune disease that may relapse except for type I diabetes under control, hypothyroidism managed with hormone replacement therapy, controlled celiac disease, and skin...
- Has a known history of interstitial lung disease, non-infectious pneumonitis, pulmonary fibrosis, acute lung disease, or dyspnea at rest or pulse oxymetrie \< 92% at room air.
- Has a clinically significant cardiovascular disease including the following:
- Myocardial infarction or unstable angina within 3 months before screening
- Congestive heart failure (New York Heart Association functional classification III-IV)
- History of clinically significant arrythmias
- QTcF \> 470 msec
- History of Mobitz II second degree or third-degree heart block without a permanent pacemaker in place
- Uncontrolled hypertension as indicated by a minimum of 2 consecutive blood pressure measurements showing systolic blood pressure \>170 mm Hg and diastolic blood pressure \>105 mmHg at screening
- Has a cognitive impairment, active substance abuse, or psychiatric illness or social situations that, in the view of the Investigator, would preclude safe treatment or the ability to give informed consent and limit...
- Has a known history of drug-induced liver injury, alcoholic liver disease, non- alcoholic steatohepatitis, primary biliary cirrhosis, ongoing extrahepatic obstruction caused by stones, cirrhosis of the liver or portal...
- Has a hemophilia or von Willebrand's disease.
- Has any psychological, familial, sociological, or geographical conditions that do not permit compliance with the protocol.
- Has a concurrent condition that, in the Investigator's opinion, would jeopardize compliance with the protocol.
- Are unable or unwilling to comply with study and/or follow-up procedures outlined in the protocol.
- For France, participants under legal protection (safeguard, guardianship, curatorship).
- Is currently participating in another therapeutic clinical study.
- Has a known hypersensitivity to polyclonal antibody.
The study team makes the final eligibility decision.
Where it's taking place
- Caen, France
- Clermont-Ferrand, France
- Créteil, France
- Pessac, France
- Pierre-Bénite, France
- Naples, Campania, Italy
- Bologna, Emilia-Romagna, Italy
- Milan, Lombardy, Italy
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Caen, France; Clermont-Ferrand, France; Créteil, France; Pessac, France; Pierre-Bénite, France; Naples, Campania, Italy and 2 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.