BridgeMD
New treatment option for Aphasia, Rehabilitation
Official title Acupuncture + Neuromodulation for Post-Stroke Aphasia
ClinicalTrials.gov ID: NCT06493747
What this study is testing
- What it's testing
- The aim of this clinical trial is to assess the therapeutic efficacy of acupuncture combined with neuromodulation techniques for the treatment of post-stroke aphasia and to explore the brain mechanisms involved. The study seeks to answer two primary questions: the effectiveness of the integrated intervention of acupuncture and repetitive transcranial magnetic stimulation (rTMS) on post-stroke aphasia, and the mechanisms underlying language function impairment and recovery.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 25 to 75. Healthy volunteers may be eligible.
You may be able to join if
- Diagnosed with aphasia following stroke according to both traditional Chinese and Western medical standards; first-time stroke in the left cerebral...
- Age between 25 and 75 years old, disease course of at least 1 month, no gender restrictions.
- Right-handed as tested by the Edinburgh Handness Inventory, with at least an elementary school education level.
- Retention of basic cognitive functions such as attention, memory, and visuospatial skills (Non-language-based Cognitive Assessment, NLCA score \>70).
- Aphasia confirmed by initial assessment with the Western Aphasia Battery (WAB); an Aphasia Quotient (AQ) \<93.8 indicates aphasia.
You likely can't join if
- Moderate to severe dysarthria as assessed by the Frenchay Dysarthria Assessment.
- Severe speech apraxia or oral-facial apraxia.
- Significant anxiety or moderate to severe depressive symptoms as assessed by the Hamilton Anxiety and Depression Scales.
- Pre-stroke speech or language disorders.
- Severe systemic diseases such as cardiopulmonary diseases that cannot tolerate rehabilitation treatment or infectious diseases.
- Significant sleep disorders or mental disorders.
See the full eligibility criteria
- Diagnosed with aphasia following stroke according to both traditional Chinese and Western medical standards; first-time stroke in the left cerebral hemisphere (including cerebral infarction and cerebral hemorrhage)...
- Age between 25 and 75 years old, disease course of at least 1 month, no gender restrictions.
- Right-handed as tested by the Edinburgh Handness Inventory, with at least an elementary school education level.
- Retention of basic cognitive functions such as attention, memory, and visuospatial skills (Non-language-based Cognitive Assessment, NLCA score \>70).
- Aphasia confirmed by initial assessment with the Western Aphasia Battery (WAB); an Aphasia Quotient (AQ) \<93.8 indicates aphasia.
- Possess a certain level of auditory comprehension and can tolerate research examinations lasting 0.5-1 hour.
- The subject and their legal guardian understand and consent to participate in this study and have jointly signed the informed consent form.
- Moderate to severe dysarthria as assessed by the Frenchay Dysarthria Assessment.
- Severe speech apraxia or oral-facial apraxia.
- Significant anxiety or moderate to severe depressive symptoms as assessed by the Hamilton Anxiety and Depression Scales.
- Pre-stroke speech or language disorders.
- Severe systemic diseases such as cardiopulmonary diseases that cannot tolerate rehabilitation treatment or infectious diseases.
- Significant sleep disorders or mental disorders.
- Pregnant or lactating women.
- Contraindications for MRI examination (presence of metal foreign bodies or other implanted electronic devices in the body).
The study team makes the final eligibility decision.
Where it's taking place
- Shanghai, Shanghai Municipality, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 25 years to 75 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Shanghai, Shanghai Municipality, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.