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New treatment option for Mucus Retention
Official title Effects of Mechanical Insufflation-Exsufflation With Optimized Settings on Wet Mucus Volume During Invasive Ventilation
ClinicalTrials.gov ID: NCT06491017
What this study is testing
- What it's testing
- Retention of airway secretions is a frequent complication in critically ill patients requiring invasive mechanical ventilation (MV).This complication is often due to excessive secretion production and ineffective secretion clearance. Mechanical insufflator-exsufflator (MI-E) is a respiratory physiotherapy technique that aims to assist or simulate a normal cough by using an electro-mechanical dedicated device.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Adults (\> 18yo).
- Endotracheal intubation and invasive mechanical ventilation for \> 48h and active humidification for \> 24h.
- Richmond Agitation-Sedation Scale -3 to -5.
- Signed informed consent.
You likely can't join if
- Patients with hemodynamic instability (MAP \ 110, Heart Rate \ 130, new onset arrhythmias), respiratory instability (PEEP \> 12cmH2O, SpO2 \ 60%).
- Undrained pneumothorax/pneumomediastinum.
- Unstable intracranial pressure (ICP \> 20mmHg or MAP \< 60).
- Severe bronchospasm.
- Post cardiothoracic surgical patients.
- Active pulmonary tuberculosis.
See the full eligibility criteria
- Adults (\> 18yo).
- Endotracheal intubation and invasive mechanical ventilation for \> 48h and active humidification for \> 24h.
- Richmond Agitation-Sedation Scale -3 to -5.
- Signed informed consent.
- Patients with hemodynamic instability (MAP \ 110, Heart Rate \ 130, new onset arrhythmias), respiratory instability (PEEP \> 12cmH2O, SpO2 \ 60%).
- Undrained pneumothorax/pneumomediastinum.
- Unstable intracranial pressure (ICP \> 20mmHg or MAP \< 60).
- Severe bronchospasm.
- Post cardiothoracic surgical patients.
- Active pulmonary tuberculosis.
- Bronchoesophageal or bronchopleural fistulas.
- Prone position.
- Pregnancy.
The study team makes the final eligibility decision.
Where it's taking place
- Barcelona, Spain
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Barcelona, Spain. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.