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New treatment option for Idiopathic Normal Pressure Hydrocephalus (INPH)
Official title Endoscopic Third Ventriculostomy vs. Ventriculoperitoneal Shunt in Idiopathic Normal Pressure Hydrocephalus (ENDOVEST)
ClinicalTrials.gov ID: NCT06488248
What this study is testing
- What it's testing
- The aim of this single-center, two-arm, open-labeled, randomized controlled clinical study is to compare two surgical interventions, endoscopic third ventriculostomy and ventriculoperitoneal shunt, in treating idiopathic normal pressure hydrocephalus in terms of clinical improvement.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 and older
You may be able to join if
- \>40 years of age
- Symptom duration ≥3 months, \<24 months
- No antecedent head trauma, ICH, meningitis, or other cause of secondary hydrocephalus
- MUST show gait/balance disturbance, PLUS cognition impairment AND/OR urinary dysfunction.
- Ventricular enlargement (Evans Index \> 0.3) not attributable to cerebral atrophy or congenital enlargement
You likely can't join if
- ≤40 years of age
- No informed consent
- Other neurologic, psychiatric or general medical condition which is sufficient to explain the presenting symptoms.
- Previous cranial neurosurgical interventions
- Other associated dementia syndromes
- Incapacity to walk
See the full eligibility criteria
- \>40 years of age
- Symptom duration ≥3 months, \<24 months
- No antecedent head trauma, ICH, meningitis, or other cause of secondary hydrocephalus
- MUST show gait/balance disturbance, PLUS cognition impairment AND/OR urinary dysfunction.
- Ventricular enlargement (Evans Index \> 0.3) not attributable to cerebral atrophy or congenital enlargement
- No macroscopic obstruction to cerebrospinal fluid (CSF) flow Spinal Tap-Test
- Opening pressure (on lateral decubitus): \<24cmH2O
- Clinical improvement in at least one of the main symptoms after 40-50ml withdrawal of CSF
- ≤40 years of age
- No informed consent
- Other neurologic, psychiatric or general medical condition which is sufficient to explain the presenting symptoms.
- Previous cranial neurosurgical interventions
- Other associated dementia syndromes
- Incapacity to walk
- Pregnancy and breastfeeding women
The study team makes the final eligibility decision.
Where it's taking place
- Basel, Switzerland
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Basel, Switzerland. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.