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New treatment option for Tuberculosis (TB)
Official title Gene-guided N-acetyl Cysteine for Prophylaxis of Anti-tuberculous Drug- Induced Hepatitis
ClinicalTrials.gov ID: NCT06484530
What this study is testing
What is N acetyl cysteine?
N acetyl cysteine is an investigational medicine, being studied as a potential treatment for tuberculosis (tb).
Also referred to as Standard anti TB drug regimen.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Tuberculosis (TB) remains a significant public health concern in Thailand and globally, especially in tropical regions, with pulmonary TB being predominant. Besides affecting the lungs, TB can also impact extrapulmonary organs.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Patients aged 18 - 80 years old.
- Newly diagnosed tuberculosis patients (both pulmonary and extrapulmonary).
- Received standard anti-tuberculosis medication according to standard regimens (2HRZE/4HR, 2HRE/7HR).
- Willing to participate in the research
You likely can't join if
- Infected with HIV.
- Severe liver dysfunction classified as Child-Pugh B or C.
- Chronic untreated liver diseases such as hepatitis B or C, alcoholic liver disease.
- Abnormal liver function tests including AST \> 1.5 times the upper limit of normal (48 U/L), ALT \> 1.5 times the upper limit of normal (55 U/L), ALP...
- Diagnosed with cancer.
- History of allergy to N-acetylcysteine (NAC).
See the full eligibility criteria
- Patients aged 18 - 80 years old.
- Newly diagnosed tuberculosis patients (both pulmonary and extrapulmonary).
- Received standard anti-tuberculosis medication according to standard regimens (2HRZE/4HR, 2HRE/7HR).
- Willing to participate in the research
- Infected with HIV.
- Severe liver dysfunction classified as Child-Pugh B or C.
- Chronic untreated liver diseases such as hepatitis B or C, alcoholic liver disease.
- Abnormal liver function tests including AST \> 1.5 times the upper limit of normal (48 U/L), ALT \> 1.5 times the upper limit of normal (55 U/L), ALP \> upper limit of normal (110 U/L), Total bilirubin \> upper limit of...
- Diagnosed with cancer.
- History of allergy to N-acetylcysteine (NAC).
- Pregnant or breastfeeding.
- Severe comorbidities such as CKD stage 4-5, chronic heart failure, severe pulmonary diseases (COPD, bronchiectasis).
The study team makes the final eligibility decision.
Where it's taking place
- Bangkok Noi, Bangkok, Thailand
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bangkok Noi, Bangkok, Thailand. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.