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New treatment option for Hereditary Spastic Paraplegia
Official title Calcium Folinate Treatment of Spastic Paraplegia 56
ClinicalTrials.gov ID: NCT06478238
What this study is testing
What is calcium folinate?
calcium folinate is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for hereditary spastic paraplegia.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- SPG56 is one of the complicated and early-onset HSP subtypes caused by genetic mutations in CYP2U1. So far, there is no standardized and specific clinical therapy for SPG56.
- Phase 1: an early, usually small safety study
- Time commitment: about 6 years
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Adults
You may be able to join if
- Patients meet the clinical diagnostic standard of hereditary spastic paraplegia (HSP);
- Spastic paraplegia type 56 (SPG56) was diagnosed by CYP2U1 pathogenic mutation;
- Patients are willing to participate in clinical trials and able to understand and comply with the research program.
You likely can't join if
- Patients are allergic to the drugs involved in the study;
- Other neurological diseases likely affecting the evaluation of study treatment;
- Other medical conditions such as: heart disease, tumor, blood disease, liver disease, kidney disease, etc. in the past 1 year;
- Pregnancy or lactating women or people who are unable to use appropriate contraception during the trial;
- Participating in another study drug trial and used the investigational drug in the past 30 days;
- people have poor compliance or other factors that are not suitable for participating in the clinical trial.
The study team makes the final eligibility decision.
Where it's taking place
- Shanghai, Shanghai Municipality, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The study runs about 6 years per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, not specified. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Shanghai, Shanghai Municipality, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.