BridgeMD
New treatment option for Patients With Non-Small Cell Lung Cancer
Official title Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung Cancer and Secondary Resistance to Immune Checkpoint Inhibitor
ClinicalTrials.gov ID: NCT06472245
What this study is testing
What is OSE2101?
OSE2101 is an investigational medicine, being studied as a potential treatment for patients with non-small cell lung cancer.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Multicenter, randomized (2:1), open-label phase 3 study in HLA-A2 positive patients with squamous and non-squamous metastatic NSCLC with ICI secondary resistance. Patients will be randomized into 2 arms (randomization 2:1): experimental Arm A with OSE2101 monotherapy or control Arm B SoC with docetaxel monotherapy.
- Phase 3: a large, late-stage study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Male or female, aged ≥ 18 years
- Patients expressing HLA-A2 phenotype in blood by pre-screening central laboratory
- Patients with histologically or cytologically squamous or non-squamous documented NSCLC, metastatic stage at study entry, not eligible for definite...
- Patients with secondary resistance to ICI; Other inclusion and
You likely can't join if
- will apply per protocol.
The study team makes the final eligibility decision.
Where it's taking place
- Beverly Hills, California, United States
- Encino, California, United States
- Los Angeles, California, United States
- Littleton, Colorado, United States
- Wheat Ridge, Colorado, United States
- Norwich, Connecticut, United States
- Washington D.C., District of Columbia, United States
- Bradenton, Florida, United States
- Brandon, Florida, United States
- Fleming Island, Florida, United States
- Jacksonville, Florida, United States
- Jacksonville Beach, Florida, United States
- Largo, Florida, United States
- Neptune Beach, Florida, United States
- Palm Harbor, Florida, United States
- Saint Augustine, Florida, United States
- St. Petersburg, Florida, United States
- Trinity, Florida, United States
- Chicago, Illinois, United States
- Merriam, Kansas, United States
+ 153 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Beverly Hills, California, United States; Encino, California, United States; Los Angeles, California, United States; Littleton, Colorado, United States; Wheat Ridge, Colorado, United States; Norwich, Connecticut, United States and 167 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.