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New treatment option for Stroke Sequelae
Official title Decoding Motor Imagery From Non-invasive Brain Recordings as a Prerequisite for Innovative Motor Rehabilitation Therapies
ClinicalTrials.gov ID: NCT06469463
What this study is testing
- What it's testing
- Seminal studies in motor neuroscience involving healthy subjects have revealed time-locked changes in induced power within specific frequency bands. Brain recordings were shown to exhibit a gradual reduction in signal power, relative to baseline, in the mu and beta frequency bands during an action or during motor imagery: the event-related desynchronization (ERD).
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Control group:
- Healthy people with age\> 18, male or female.
- Right handed (Due to the fact that unlike right-handed people, left-handed people tend to have more complicated somatotopic organization of the motor...
- Registered with the French healthcare system.
- Motivated to participate in the study.
You likely can't join if
- people with characteristics incompatible with MEG and MRI : 1\. Claustrophobia.
- people with motor impairment (only applies to control group), severe traumatic brain injury.
- people with chronic stroke (applies to both groups).
- people history of skin disease or skin allergies (multiple or severe).
- people who:
- have had an MRI within 2 weeks prior to the experiment.
See the full eligibility criteria
- Control group:
- Healthy people with age\> 18, male or female.
- Right handed (Due to the fact that unlike right-handed people, left-handed people tend to have more complicated somatotopic organization of the motor cortex, we will avoid confounding observed differences to differences...
- Registered with the French healthcare system.
- Motivated to participate in the study.
- Normal or corrected vision.
- Adequate knowledge of French language to be able to follow directions.
- people must be able to listen and understand the study instructions.
- people must be able to give written informed consent before participation.
- No history of neurological or psychiatric disease.
- No physical disability of the arms or wrists.
- No use of drugs affecting the central nervous system or self-reported abuse of any drugs. Patient group :
- Male or female stroke patients over 18 years old.
- Stroke patients must be not be in the acute phase of stroke.
- Right-handed.
- Having motor disorders in at least one of the upper limbs following the stroke, possibly with moderate accompanying deficits but no cognitive deficits.
- Entitled to a social security scheme.
- Motivated to participate in the study.
- Having normal or corrected vision.
- Having a sufficient understanding of the French language to be able to follow directions.
- Able to listen and understand study instructions.
- Able to give their written informed consent before participating.
- people with characteristics incompatible with MEG and MRI : 1\. Claustrophobia.
- people with motor impairment (only applies to control group), severe traumatic brain injury.
- people with chronic stroke (applies to both groups).
- people history of skin disease or skin allergies (multiple or severe).
- people who:
- have had an MRI within 2 weeks prior to the experiment.
- have implanted materials (any dental apparatus containing metal including or root canals or any metallic object, pacemaker, cochlear implanted in the body).
- people working with metals in their professional lives.
- Pregnant or lactating women Pregnant or lactating women (check with a urinary test).
- people who are not able to tolerate sitting for longer than 2 hours (the estimated length of an experimental session is about 2h30mins).
- people with alcohol dependence (no consumption of alcohol or drugs at least 24 hours prior to the day of experiments).
- people currently taking a medication that may have a strong effect on MEG or EEG recordings (e.g., antidepressants, stimulant medication, etc).
- people who, in the opinion of the investigator, are not able or willing to comply with the protocol.
- Persons under guardianship or curatorship.
- Persons in emergency situations who cannot give their consent.
- people under 18 years of age.
- people under legal protection measures.
- Volunteers with contraindications to MEG examination
- Pacemaker.
- Implanted pump including insulin pump.
- Neurostimulator.
- Cochlear implants or other hearing aids.
- Metal prosthesis.
- Intracerebral / surgical aneurysm clips.
- Ocular or cerebral ferromagnetic foreign bodies in the upper body.
- Neurosurgical ventriculoperitoneal shunt valves.
The study team makes the final eligibility decision.
Where it's taking place
- Bron, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bron, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.