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New treatment option for Posttraumatic Stress Disorder
Official title Multimodal Image Analysis and Guidance of Neuromodulation for Trauma-Related Symptoms
ClinicalTrials.gov ID: NCT06449326
What this study is testing
- What it's testing
- MAGNETS is a prospective, randomized, parallel-design, sham-controlled clinical trial of accelerated, functional magnetic resonance imaging (fMRI)-guided intermittent theta burst stimulation (iTBS) to the right dorsolateral prefrontal cortex (dlPFC) for chronic symptoms of posttraumatic stress disorder (PTSD) in a comorbid Veteran population.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Veterans will be enrolled in this study if they:
- are aged 18-80;
- have a documented diagnosis of PTSD with evidence of ongoing symptoms as demonstrated by score of "31" or higher on the PCL-5, a measure of...
- are fluent in English (as the neuropsychological testing tools used are only available in English) and
- have been on stable doses of psychotropic medications for the past month.
You likely can't join if
- Veterans will be excluded from participation in this study if there is:
- a prior history of other neurological disease beyond mild TBI, as determined by VA/DoD criteria for TBI severity;
- any history of seizures beyond immediate posttraumatic seizure or childhood febrile seizure, so as to reduce risk of exacerbation of epilepsy or...
- history of a psychotic disorder, such as schizophrenia or bipolar disorder, so as to reduce risk of psychiatric decompensation;
- active substance/alcohol dependence without ongoing treatment, to reduce confounding effects on diagnosis and brain imaging;
- presence of any implanted electrical device (e.g., pacemaker), to reduce risk of device malfunction from rTMS;
See the full eligibility criteria
- Veterans will be enrolled in this study if they:
- are aged 18-80;
- have a documented diagnosis of PTSD with evidence of ongoing symptoms as demonstrated by score of "31" or higher on the PCL-5, a measure of posttraumatic stress symptoms;
- are fluent in English (as the neuropsychological testing tools used are only available in English) and
- have been on stable doses of psychotropic medications for the past month.
- Veterans will be excluded from participation in this study if there is:
- a prior history of other neurological disease beyond mild TBI, as determined by VA/DoD criteria for TBI severity;
- any history of seizures beyond immediate posttraumatic seizure or childhood febrile seizure, so as to reduce risk of exacerbation of epilepsy or other neurological symptoms;
- history of a psychotic disorder, such as schizophrenia or bipolar disorder, so as to reduce risk of psychiatric decompensation;
- active substance/alcohol dependence without ongoing treatment, to reduce confounding effects on diagnosis and brain imaging;
- presence of any implanted electrical device (e.g., pacemaker), to reduce risk of device malfunction from rTMS;
- recent medical hospitalization (within four weeks), to reduce risk of medical decompensation during the study;
- any condition that would prevent the subject from completing the protocol;
- appointment of a legal representative or inability to provide informed consent, to avoid coercion of a vulnerable population;
- any ongoing litigation related to PTSD, TBI, disability determination, or service connection, to prevent interference with legal proceedings;
- any contraindication to MRI;
- pregnant women, so as to prevent complications;
- membership in an identified vulnerable population, including minors and prisoners, so as to prevent coercion;
- Cognitively impaired adults who lack capacity to consent.
The study team makes the final eligibility decision.
Where it's taking place
- Albuquerque, New Mexico, United States
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Albuquerque, New Mexico, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.