BridgeMD
New treatment option for Stimulant Use
Official title Accelerated rTMS for Substance Use Disorder and Depression
ClinicalTrials.gov ID: NCT06424184
What this study is testing
- What it's testing
- This study is a small open-label feasibility trial of an accelerated course of repetitive transcranial magnetic stimulation (rTMS) for individuals with depression and stimulant use disorder [including methamphetamine or cocaine use disorder (MUD/CUD)].
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Be aged 18-65 years, inclusive.
- Be able to sufficiently understand, speak, and read English to provide informed consent and ask relevant questions, and be willing to comply with all...
- Self-report stimulant use (cocaine, methamphetamine, or prescription stimulants) at least 10 days in the 30-day period prior to consent.
- Have a diagnosis of moderate or severe Cocaine or Methamphetamine Use Disorder (CUD/MUD) or other Stimulant Use Disorder over the past 12 months (as...
- Have a PHQ9 of greater than or equal to five (5).
You likely can't join if
- Have a current pattern of alcohol, benzodiazepine, or other sedative/hypnotic use that would preclude safe participation in the study, as determined...
- Have a history of a serious medical disorder that, in the opinion of the PI or their designee, would make it unsafe to participate in the study or...
- Have a documented history of unprovoked seizure (lifetime) or any seizure in the past 6 months.
- Have a documented history of brain lesion(s) and/or tumor(s).
- Have metal implants or non-removable metal objects above the neck.
- Current pregnancy as determined by a urine screening.
See the full eligibility criteria
- Be aged 18-65 years, inclusive.
- Be able to sufficiently understand, speak, and read English to provide informed consent and ask relevant questions, and be willing to comply with all study procedure instructions.
- Self-report stimulant use (cocaine, methamphetamine, or prescription stimulants) at least 10 days in the 30-day period prior to consent.
- Have a diagnosis of moderate or severe Cocaine or Methamphetamine Use Disorder (CUD/MUD) or other Stimulant Use Disorder over the past 12 months (as determined by the MINI International Neuropsychiatric Interview).
- Have a PHQ9 of greater than or equal to five (5).
- Be willing to provide urine samples, EEGs, and ECGs.
- Be willing to use appropriate birth control method during the treatment phase of the study, if individual is of childbearing potential.
- Have a current pattern of alcohol, benzodiazepine, or other sedative/hypnotic use that would preclude safe participation in the study, as determined by the PI or their designee.
- Have a history of a serious medical disorder that, in the opinion of the PI or their designee, would make it unsafe to participate in the study or may prevent collection of study data (e.g., disabling terminal diagnosis...
- Have a documented history of unprovoked seizure (lifetime) or any seizure in the past 6 months.
- Have a documented history of brain lesion(s) and/or tumor(s).
- Have metal implants or non-removable metal objects above the neck.
- Current pregnancy as determined by a urine screening.
- Current or lifetime manic or hypomanic episode, defined by MINI diagnostic interview.
- Current psychotic disorder.
- Are a prisoner or in police custody at the time of eligibility screening.
The study team makes the final eligibility decision.
Where it's taking place
- Dallas, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Dallas, Texas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.