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Compares treatment options for Graft-Versus-Host Disease
Official title Prospective Clinical Trial for Children With TCRαβ Depleted vs Traditional Haplo Identicle HSCT
ClinicalTrials.gov ID: NCT06423131
What this study is testing
- What it's testing
- This is a single-center prospective, non-randomized controlled clinical study in China using CliniMACS TCRα/β+ cell depleted stem cell haploidentical donors versus conventional Beijing protocol for haploidentical hematopoietic stem cell transplantation in children.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 8 to 18
You may be able to join if
- Age 8 weeks to 18 years
- Children who meet the indicators haploidentical hematopoietic cell transplantation
- No HLA ≥ 9/10 donor or not suitable for this type of donor due to illness
- Informed consent must be signed (by the patient or legal representative)
You likely can't join if
- Liver function abnormalities with bilirubin \>2 mg/dL and elevation of transaminases higher than 400 U/L
- Chronic active viral hepatitis
- Ejection fraction \<50%
- Respiratory failure necessitating supplemental oxygen
- Patients with a history of psychiatric illness or a condition which could interfere with their ability to understand the requirements of the study
- Patients unwilling or unable to comply with the protocol or unable to give informed consent
See the full eligibility criteria
- Age 8 weeks to 18 years
- Children who meet the indicators haploidentical hematopoietic cell transplantation
- No HLA ≥ 9/10 donor or not suitable for this type of donor due to illness
- Informed consent must be signed (by the patient or legal representative)
- Liver function abnormalities with bilirubin \>2 mg/dL and elevation of transaminases higher than 400 U/L
- Chronic active viral hepatitis
- Ejection fraction \<50%
- Respiratory failure necessitating supplemental oxygen
- Patients with a history of psychiatric illness or a condition which could interfere with their ability to understand the requirements of the study
- Patients unwilling or unable to comply with the protocol or unable to give informed consent
- Concurrent severe or uncontrolled infection
The study team makes the final eligibility decision.
Where it's taking place
- Shanghai, Shanghai Municipality, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 8 weeks to 18 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Shanghai, Shanghai Municipality, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.