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New treatment option for Age-related Cognitive Decline
Official title Cardiac-Control Affecting Learning Through Mindfulness (CALM)
ClinicalTrials.gov ID: NCT06410157
What this study is testing
- What it's testing
- Some types of meditation lead heart rate to become more steady as breathing quiets whereas others lead to large heart rate swings up and down (oscillations) as breathing becomes deeper and slower. The current study is designed to investigate how daily mindfulness practice with heart rate biofeedback during breathing in a pattern that either increases or decreases heart rate oscillation affect attention and memory and blood biomarkers associated with Alzheimer's disease.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 to 70. Healthy volunteers may be eligible.
You may be able to join if
- Fluent in English
- Black/African-American or White/European-American
- Aged between 50-70 years old
- Non-pregnant and non-menstruating (for at least the past year)
- Have normal or corrected-to-normal vision and hearing
You likely can't join if
- Have a disorder that would impede performing the breathing intervention (e.g., abnormal cardiac rhythm, arrhythmia, dyspnea)
- Have cognitive impairment
- Have regularly played Lumosity games in the past 6 months
- Have any conditions listed below that are not safe for MRI
- \ Metal in any parts of your body
- Claustrophobia
See the full eligibility criteria
- Fluent in English
- Black/African-American or White/European-American
- Aged between 50-70 years old
- Non-pregnant and non-menstruating (for at least the past year)
- Have normal or corrected-to-normal vision and hearing
- Have reliable access to wifi
- Have an email account that you check regularly
- Have a phone that receives text messages
- Agree to provide blood and urine samples at two campus visits
- Agree to devote up to 50 minutes daily to this study for 10 weeks as well as attend two campus visits
- Have a disorder that would impede performing the breathing intervention (e.g., abnormal cardiac rhythm, arrhythmia, dyspnea)
- Have cognitive impairment
- Have regularly played Lumosity games in the past 6 months
- Have any conditions listed below that are not safe for MRI
- \ Metal in any parts of your body
- Claustrophobia
- Have worked as a machinist, metal worker, or in any profession or hobby grinding metal?
- Have had an injury to the eye involving a metallic object (e.g., metallic slivers, shavings, or foreign body)
- Cardiac pacemaker
- Implanted cardiac defibrillator
- Aneurysm clip or brain clip
- Carotid artery vascular clamp
- Neurostimulator
- Insulin or infusion pump
- Spinal fusion stimulator
- Cochlear, otologic, ear tubes or ear implant
- Prosthesis (eye/orbital, penile, etc.)
- Implant held in place by a magnet
- Heart valve prosthesis
- Artificial limb or joint
- Other implants in body or head
- Electrodes (on body, head or brain)
- Intravascular stents, filters
- Shunt (spinal or intraventricular)
- Vascular access port or catheters
- Transdermal delivery system or other types of foil patches (e.g., Nitro, Nicotine, Birth control, etc.) that cannot be removed for MRI
- Shrapnel, buckshot, or bullets
- Tattooed eyeliner or eyebrows
- Body piercing(s) that cannot be removed for MRI
- Metal fragments (eye, head, ear, skin)
- Internal pacing wires
- Aortic clips
- Metal or wire mesh implants
- Wire sutures or surgical staples
- Harrington rods (spine)
- Bone/joint pin, screw, nail, wire, plate
- Wig or toupee that cannot be removed for MRI
- Hair implants that involve staples or metal
- Hearing aid(s) that cannot be removed for MRI
- Dentures or retainers that cannot be removed for MRI
The study team makes the final eligibility decision.
Where it's taking place
- Los Angeles, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years to 70 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Los Angeles, California, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.