BridgeMD
New treatment option for Postoperative Analgesia
Official title Oliceridine-Enhanced Analgesia and Recovery: A G-Protein Biased μ-Opioid Study
ClinicalTrials.gov ID: NCT06409689
What this study is testing
What is Oliceridine fumarate low dose?
Oliceridine fumarate low dose is an investigational medicine, given as an once-daily, being studied as a potential treatment for postoperative analgesia.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Identifying the lowest effective opioid dose that achieves rapid pain relief while minimizing side effects is a principal objective in postoperative multimodal analgesia strategies. This study aims to determine the optimal analgesic regimen and dosage by assessing the clinical efficacy of oliceridine for postoperative pain management.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70
You may be able to join if
- ASA grades 1-2
- Age \> 18 years and \< 70 years
- Laparoscopic upper abdominal surgery under general anesthesia is planned, and the operation time is not more than 4 hours
- Voluntarily receive postoperative controlled intravenous analgesia
- people understand and can cooperate with this study
You likely can't join if
- BMI\>30 kg/m2 or \< 19 kg/m2
- Patients with preoperative use of opioids, acute and chronic pain or hyperalgesia
- Patients with coronary atherosclerotic heart disease, significant ischemic heart disease, severe angina, heart failure, valvular disease or other...
- More severe hepatic and renal insufficiency
- A history of mental illness or alcoholism
- A history of alcohol or drug abuse
See the full eligibility criteria
- ASA grades 1-2
- Age \> 18 years and \< 70 years
- Laparoscopic upper abdominal surgery under general anesthesia is planned, and the operation time is not more than 4 hours
- Voluntarily receive postoperative controlled intravenous analgesia
- people understand and can cooperate with this study
- people can provide and sign written informed consent prior to conducting investigation-related screening procedures
- BMI\>30 kg/m2 or \< 19 kg/m2
- Patients with preoperative use of opioids, acute and chronic pain or hyperalgesia
- Patients with coronary atherosclerotic heart disease, significant ischemic heart disease, severe angina, heart failure, valvular disease or other heart disease
- More severe hepatic and renal insufficiency
- A history of mental illness or alcoholism
- A history of alcohol or drug abuse
- Combined with cranial pressure, intraocular pressure or glaucoma
- Poorly controlled or untreated hypertension before surgery
- Preeclampsia or eclampsia
- Untreated and undertreated hyperthyroidism
- Combined with autoimmune disease
- Unable to use the numerical rating scale
- History of chronic cough
- Surgery is expected to take more than 4 hours Patients enrolled in other clinical trials within 3 months
The study team makes the final eligibility decision.
Where it's taking place
- Wuhan, Hubei, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Wuhan, Hubei, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.