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Compares treatment options for Major Depressive Disorder (MDD)
Official title Effectiveness of MST Versus ECT for Major Depressive Episode
ClinicalTrials.gov ID: NCT06409325
What this study is testing
- What it's testing
- Despite advancements in Magnetic Seizure Therapy (MST) and Electroconvulsive Therapy (ECT) for Major Depressive Disorder (MDD), there remains a need for further research to replicate clinical outcomes and understand the therapeutic targets of these treatments. This study aims to address these gaps through a double-blinded, randomized, non-inferiority investigation comparing the efficacy, tolerability, cognitive adverse effects, and neurophysiological biomarkers of MST and bilateral ECT in patients with MDD.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Participants must meet the diagnostic criteria for MDD as outlined in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition...
- Participants must have a baseline score of 18 or higher on the 24-item Hamilton Depression Rating Scale (HDRS-24).
- During the trial's treatment period, participants must be using a single antidepressant medication at a stable dose.
- Participants must be between the ages of 18 and 65 years.
- Informed consent from both parents and legal guardians is required.
You likely can't join if
- Individuals with current or history of organic brain disorders or neurological disorders will be excluded from the study.
- Participants with a Wechsler Abbreviated Scale of Intelligence (WASI) score of less than 70 will be excluded.
- Individuals currently taking antiepileptic drugs, benzodiazepines, or other medications that may affect seizure activity will be excluded from the...
- Those with exposure to ECT, modified ECT, MST, transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), transcranial...
- Individuals with cochlear implants, cardiac pacemakers, implanted devices, or metal in the brain will be excluded from participation.
- Pregnant or lactating individuals will be excluded from the study.
See the full eligibility criteria
- Participants must meet the diagnostic criteria for MDD as outlined in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5).
- Participants must have a baseline score of 18 or higher on the 24-item Hamilton Depression Rating Scale (HDRS-24).
- During the trial's treatment period, participants must be using a single antidepressant medication at a stable dose.
- Participants must be between the ages of 18 and 65 years.
- Informed consent from both parents and legal guardians is required.
- Individuals with current or history of organic brain disorders or neurological disorders will be excluded from the study.
- Participants with a Wechsler Abbreviated Scale of Intelligence (WASI) score of less than 70 will be excluded.
- Individuals currently taking antiepileptic drugs, benzodiazepines, or other medications that may affect seizure activity will be excluded from the study.
- Those with exposure to ECT, modified ECT, MST, transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), or other neurostimulation...
- Individuals with cochlear implants, cardiac pacemakers, implanted devices, or metal in the brain will be excluded from participation.
- Pregnant or lactating individuals will be excluded from the study.
- Individuals currently participating in another concurrent clinical trial will not be eligible for inclusion.
- Participants who refuse to provide informed consent to participate in the trial will be excluded.
- Other circumstances deemed unsuitable for participation by researchers will result in exclusion.
The study team makes the final eligibility decision.
Where it's taking place
- Shanghai, Shanghai Municipality, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Shanghai, Shanghai Municipality, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.